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dc.rights.licenseopenen_US
dc.contributor.authorDICHGANS, Martin
dc.contributor.authorBEAUFORT, Nathalie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorANDERSON, Christopher D.
dc.date.accessioned2021-10-01T10:20:50Z
dc.date.available2021-10-01T10:20:50Z
dc.date.issued2021-08
dc.identifier.issn0039-2499en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112515
dc.description.abstractEnThe field of medical and population genetics in stroke is moving at a rapid pace and has led to unanticipated opportunities for discovery and clinical applications. Genome-wide association studies have highlighted the role of specific pathways relevant to etiologically defined subtypes of stroke and to stroke as a whole. They have further offered starting points for the exploration of novel pathways and pharmacological strategies in experimental systems. Mendelian randomization studies continue to provide insights in the causal relationships between exposures and outcomes and have become a useful tool for predicting the efficacy and side effects of drugs. Additional applications that have emerged from recent discoveries include risk prediction based on polygenic risk scores and pharmacogenomics. Among the topics currently moving into focus is the genetics of stroke outcome. While still at its infancy, this field is expected to boost the development of neuroprotective agents. We provide a brief overview on recent progress in these areas.
dc.language.isoENen_US
dc.subject.enBlood pressure
dc.subject.enLipoprotein
dc.subject.enGenetics
dc.subject.enCoronary artery disease
dc.subject.enCardiovascular disease
dc.title.enStroke Genetics: Turning Discoveries into Clinical Applications
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/strokeaha.121.032616en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34399583en_US
bordeaux.journalStrokeen_US
bordeaux.page2974-2982en_US
bordeaux.volume52en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03361315
hal.version1
hal.date.transferred2021-10-01T10:20:54Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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