Afficher la notice abrégée

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

dc.rights.licenseopenen_US
dc.contributor.authorBASTARD, Paul
dc.contributor.authorGERVAIS, Adrian
dc.contributor.authorLE VOYER, Tom
dc.contributor.authorROSAIN, Jeremie
dc.contributor.authorPHILIPPOT, Quentin
dc.contributor.authorMANRY, Jeremy
dc.contributor.authorMICHAILIDIS, Eleftherios
dc.contributor.authorHOFFMANN, Hans-Heinrich
dc.contributor.authorETO, Shohei
dc.contributor.authorGARCIA-PRAT, Marina
dc.contributor.authorBIZIEN, Lucy
dc.contributor.authorPARRA-MARTINEZ, Alba
dc.contributor.authorYANG, Rui
dc.contributor.authorHALJASMAGI, Liis
dc.contributor.authorMIGAUD, Melanie
dc.contributor.authorSAREKANNU, Karita
dc.contributor.authorMASLOVSKAJA, Julia
dc.contributor.authorDE PROST, Nicolas
dc.contributor.authorTANDJAOUI-LAMBIOTTE, Yacine
dc.contributor.authorLUYT, Charles-Edouard
dc.contributor.authorAMADOR-BORRERO, Blanca
dc.contributor.authorGAUDET, Alexandre
dc.contributor.authorPOISSY, Julien
dc.contributor.authorMOREL, Pascal
dc.contributor.authorRICHARD, Pascale
dc.contributor.authorCOGNASSE, Fabrice
dc.contributor.authorTROYA, Jesus
dc.contributor.authorTROUILLET-ASSANT, Sophie
dc.contributor.authorBELOT, Alexandre
dc.contributor.authorSAKER, Kahina
dc.contributor.authorGARCON, Pierre
dc.contributor.authorRIVIERE, Jacques G.
dc.contributor.authorLAGIER, Jean-Christophe
dc.contributor.authorGENTILE, Stephanie
dc.contributor.authorROSEN, Lindsey B.
dc.contributor.authorSHAW, Elana
dc.contributor.authorMORIO, Tomohiro
dc.contributor.authorTANAKA, Junko
dc.contributor.authorDALMAU, David
dc.contributor.authorTHARAUX, Pierre-Louis
dc.contributor.authorSENE, Damien
dc.contributor.authorSTEPANIAN, Alain
dc.contributor.authorMEGARBANE, Bruno
dc.contributor.authorTRIANTAFYLLIA, Vasiliki
dc.contributor.authorFEKKAR, Arnaud
dc.contributor.authorHEATH, James R.
dc.contributor.authorFRANCO, Jose Luis
dc.contributor.authorANAYA, Juan-Manuel
dc.contributor.authorSOLE-VIOLAN, Jordi
dc.contributor.authorIMBERTI, Luisa
dc.contributor.authorBIONDI, Andrea
dc.contributor.authorBONFANTI, Paolo
dc.contributor.authorCASTAGNOLI, Riccardo
dc.contributor.authorDELMONTE, Ottavia M.
dc.contributor.authorZHANG, Yu
dc.contributor.authorSNOW, Andrew L.
dc.contributor.authorHOLLAND, Steven M.
dc.contributor.authorBIGGS, Catherine
dc.contributor.authorMONCADA-VELEZ, Marcela
dc.contributor.authorARIAS, Andres Augusto
dc.contributor.authorLORENZO, Lazaro
dc.contributor.authorBOUCHERIT, Soraya
dc.contributor.authorCOULIBALY, Boubacar
dc.contributor.authorANGLICHEAU, Dany
dc.contributor.authorPLANAS, Anna M.
dc.contributor.authorHAERYNCK, Filomeen
dc.contributor.authorDUVLIS, Sotirija
dc.contributor.authorNUSSBAUM, Robert L.
dc.contributor.authorOZCELIK, Tayfun
dc.contributor.authorKELES, Seygi
dc.contributor.authorBOUSFIHA, Ahmed A.
dc.contributor.authorEL BAKKOURI, Jalila
dc.contributor.authorRAMIREZ-SANTANA, Carolina
dc.contributor.authorPAUL, Stephane
dc.contributor.authorPAN-HAMMARSTROM, Qiang
dc.contributor.authorHAMMARSTROM, Lennart
dc.contributor.authorDUPONT, Annabelle
dc.contributor.authorKUROLAP, Alina
dc.contributor.authorMETZ, Christine N.
dc.contributor.authorAIUTI, Alessandro
dc.contributor.authorCASARI, Giorgio
dc.contributor.authorLAMPASONA, Vito
dc.contributor.authorCICERI, Fabio
dc.contributor.authorBARREIROS, Lucile A.
dc.contributor.authorDOMINGUEZ-GARRIDO, Elena
dc.contributor.authorVIDIGAL, Mateus
dc.contributor.authorZATZ, Mayana
dc.contributor.authorVAN DE BEEK, Diederik
dc.contributor.authorSAHANIC, Sabina
dc.contributor.authorTANCEVSKI, Ivan
dc.contributor.authorSTEPANOVSKYY, Yurii
dc.contributor.authorBOYARCHUK, Oksana
dc.contributor.authorNUKUI, Yoko
dc.contributor.authorTSUMURA, Miyuki
dc.contributor.authorVIDAUR, Loreto
dc.contributor.authorTANGYE, Stuart G.
dc.contributor.authorBURREL, Sonia
dc.contributor.authorDUFFY, Darragh
dc.contributor.authorQUINTANA-MURCI, Lluis
dc.contributor.authorKLOCPERK, Adam
dc.contributor.authorKANN, Nelli Y.
dc.contributor.authorSHCHERBINA, Anna
dc.contributor.authorLAU, Yu-Lung
dc.contributor.authorLEUNG, Daniel
dc.contributor.authorCOULONGEAT, Matthieu
dc.contributor.authorMARLET, Julien
dc.contributor.authorKONING, Rutger
dc.contributor.authorREYES, Luis Felipe
dc.contributor.authorCHAUVINEAU-GRENIER, Angelique
dc.contributor.authorVENET, Fabienne
dc.contributor.authorMONNERET, Guillaume
dc.contributor.authorNUSSENZWEIG, Michel C.
dc.contributor.authorARRESTIER, Romain
dc.contributor.authorBOUDHABHAY, Idris
dc.contributor.authorBARIS-FELDMAN, Hagit
dc.contributor.authorHAGIN, David
dc.contributor.authorWAUTERS, Joost
dc.contributor.authorMEYTS, Isabelle
dc.contributor.authorDYER, Adam H.
dc.contributor.authorKENNELLY, Sean P.
dc.contributor.authorBOURKE, Nollaig M.
dc.contributor.authorHALWANI, Rabih
dc.contributor.authorSHARIF-ASKARI, Narjes Saheb
dc.contributor.authorDORGHAM, Karim
dc.contributor.authorSALLETTE, Jerome
dc.contributor.authorSEDKAOUI, Souad Mehlal
dc.contributor.authorALKHATER, Suzan
dc.contributor.authorRIGO-BONNIN, Raul
dc.contributor.authorMORANDEIRA, Francisco
dc.contributor.authorROUSSEL, Lucie
dc.contributor.authorVINH, Donald C.
dc.contributor.authorOSTROWSKI, Sisse Rye
dc.contributor.authorCONDINO-NETO, Antonio
dc.contributor.authorPRANDO, Carolina
dc.contributor.authorBONRADENKO, Anastasiia
dc.contributor.authorSPAAN, Andras N.
dc.contributor.authorGILARDIN, Laurent
dc.contributor.authorFELLAY, Jacques
dc.contributor.authorLYONNET, Stanislas
dc.contributor.authorBILGUVAR, Kaya
dc.contributor.authorLIFTON, Richard P.
dc.contributor.authorMANE, Shrikant
dc.contributor.authorLAB, Hgid
dc.contributor.authorCLINICIANS, Covid
dc.contributor.authorCLINICIANS, Covid-Storm
dc.contributor.authorGROUP, Niaid Immune Response To COVID
dc.contributor.authorGROUP, Nh-Covair Study
dc.contributor.authorDANISH, Chge
dc.contributor.authorDANISH BLOOD DONOR, Study
dc.contributor.authorST. JAMES'S, Hospital
dc.contributor.authorGROUP, Sars CoV2 Interest
dc.contributor.authorFRENCH, Covid Cohort Study Group
dc.contributor.authorIMAGINE, Covid-Group
dc.contributor.authorMILIEU INTERIEUR, Consortium
dc.contributor.authorCO, V. Contact Cohort
dc.contributor.authorAMSTERDAM, U. M. C. Covid
dc.contributor.authorBIOBANK, Investigators
dc.contributor.authorEFFORT, Covid Human Genetic
dc.contributor.authorCOHORT, Constances
dc.contributor.authorSTUDY, C. Dijon
dc.contributor.authorCERBA, Health-Care
dc.contributor.authorETABLISSEMENT DU SANG STUDY, Group
dc.contributor.authorANDERSON, Mark S.
dc.contributor.authorBOISSON, Bertrand
dc.contributor.authorBEZIAT, Vivien
dc.contributor.authorZHANG, Shen-Ying
dc.contributor.authorVANDREAKOS, Evangelos
dc.contributor.authorHERMINE, Olivier
dc.contributor.authorPUJOL, Aurora
dc.contributor.authorPETERSON, Part
dc.contributor.authorMOGENSEN, Trine H.
dc.contributor.authorROWEN, Lee
dc.contributor.authorMOND, James
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDE LAMBALLERIE, Xavier
dc.contributor.authorDUVAL, Xavier
dc.contributor.authorMENTRE, France
dc.contributor.authorZINS, Marie
dc.contributor.authorSOLER-PALACIN, Pere
dc.contributor.authorCOLOBRAN, Roger
dc.contributor.authorGOROCHOV, Guy
dc.contributor.authorSOLANICH, Xavier
dc.contributor.authorSUSEN, Sophie
dc.contributor.authorMARTINEZ-PICADO, Javier
dc.contributor.authorRAOULT, Didier
dc.contributor.authorVASSE, Marc
dc.contributor.authorGREGERSEN, Peter K.
dc.contributor.authorPIEMONTI, Lorenzo
dc.contributor.authorRODRIGUEZ-GALLEGO, Carlos
dc.contributor.authorNOTARANGELO, Luigi D.
dc.contributor.authorSU, Helen C.
dc.contributor.authorKISAND, Kai
dc.contributor.authorOKADA, Satoshi
dc.contributor.authorPUEL, Anne
dc.contributor.authorJOUANGUY, Emmanuelle
dc.contributor.authorRICE, Charles M.
dc.contributor.authorTIBERGHIEN, Pierre
dc.contributor.authorZHANG, Qian
dc.contributor.authorCOBAT, Aurelie
dc.contributor.authorABEL, Laurent
dc.contributor.authorCASANOVA, Jean-Laurent
dc.date.accessioned2021-09-29T13:59:29Z
dc.date.available2021-09-29T13:59:29Z
dc.date.issued2021-08-19
dc.identifier.issn2470-9468en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112480
dc.description.abstractEnCirculating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.
dc.description.sponsorshipIdentification des défauts monogéniques de l'immunité responsables des formes sévères de COVID-19 chez les patients précédemment en bonne santéen_US
dc.description.sponsorshipAnalyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévèresen_US
dc.description.sponsorshipBases génétiques et immunologiques des auto-anticorps contre les interférons de type I prédisposant aux formes sévères de COVID-19.en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enAutoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
dc.typeArticle de revueen_US
dc.identifier.doi10.1126/sciimmunol.abl4340en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34413139en_US
dc.description.sponsorshipEuropeProgram Initiative d’Excellenceen_US
bordeaux.journalScience Immunologyen_US
bordeaux.volume6en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue62en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDHoward Hughes Medical Instituteen_US
bordeaux.identifier.funderIDRockefeller Universityen_US
bordeaux.identifier.funderIDSt. Giles Foundationen_US
bordeaux.identifier.funderIDNational Human Genome Research Instituteen_US
bordeaux.identifier.funderIDMeyer Foundationen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDFondation du Souffleen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDMinistère des Solidarités et de la Santéen_US
bordeaux.identifier.funderIDEuropean Commissionen_US
bordeaux.identifier.funderIDSorbonne Universitéen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDConseil régional de Bourgogne-Franche-Comtéen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDNational Cancer Instituteen_US
bordeaux.identifier.funderIDInstituto de Salud Carlos IIIen_US
bordeaux.identifier.funderIDEuropean Regional Development Funden_US
bordeaux.identifier.funderIDFundación DISAen_US
bordeaux.identifier.funderIDMinistero della Saluteen_US
bordeaux.identifier.funderIDJeffrey Modell Foundationen_US
bordeaux.identifier.funderIDMeath Foundationen_US
hal.identifierhal-03358792
hal.version1
hal.date.transferred2021-09-29T13:59:50Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Science%20Immunology&amp;rft.date=2021-08-19&amp;rft.volume=6&amp;rft.issue=62&amp;rft.eissn=2470-9468&amp;rft.issn=2470-9468&amp;rft.au=BASTARD,%20Paul&amp;GERVAIS,%20Adrian&amp;LE%20VOYER,%20Tom&amp;ROSAIN,%20Jeremie&amp;PHILIPPOT,%20Quentin&amp;rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_SI_2021_Bastard.pdf
Taille:
4.359Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée