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Diabetes Mellitus and Cognition: A Pathway Analysis in the MEMENTO Cohort

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFRISON, Eric
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cecile
dc.contributor.authorMANGIN, Jean-Francois
dc.contributor.authorHABERT, Marie-Odile
dc.contributor.authorBOMBOIS, Stephanie
dc.contributor.authorOUSSET, Pierre-Jean
dc.contributor.authorPASQUIER, Florence
dc.contributor.authorHANON, Olivier
dc.contributor.authorPAQUET, Claire
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorCECCALDI, Mathieu
dc.contributor.authorANNWEILER, Cedric
dc.contributor.authorKROLAK-SALMON, Pierre
dc.contributor.authorBEJOT, Yannick
dc.contributor.authorBELIN, Catherine
dc.contributor.authorWALLON, David
dc.contributor.authorSAUVEE, Mathilde
dc.contributor.authorBEAUFILS, Emilie
dc.contributor.authorBOURDEL-MARCHASSON, Isabelle
dc.contributor.authorJALENQUES, Isabelle
dc.contributor.authorCHUPIN, Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorGROUP, Memento Cohort Study
dc.date.accessioned2021-08-27T14:49:48Z
dc.date.available2021-08-27T14:49:48Z
dc.date.issued2021-07-01
dc.identifier.issn0028-3878en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110237
dc.description.abstractEnOBJECTIVE: To assess the role of biomarkers of Alzheimer's Disease (AD), neurodegeneration and small vessel disease (SVD) as mediators in the association between diabetes mellitus and cognition. METHODS: The study sample was derived from MEMENTO, a cohort of French adults recruited in memory clinics and screened for either isolated subjective cognitive complaints or mild cognitive impairment. Diabetes was defined based on blood glucose assessment, use of antidiabetic agent or self-report. We used structural equation modelling to assess whether latent variables of AD pathology (PET mean amyloid uptake, Aβ(42)/Aβ(40) ratio and CSF phosphorylated tau), SVD (white matter hyperintensities volume and visual grading), and neurodegeneration (mean cortical thickness, brain parenchymal fraction, hippocampal volume, and mean fluorodeoxyglucose uptake) mediate the association between diabetes and a latent variable of cognition (five neuropsychological tests), adjusting for potential confounders. RESULTS: There were 254 (11.1%) participants with diabetes among 2,288 participants (median age 71.6 years; 61.8% women). The association between diabetes and lower cognition was significantly mediated by higher neurodegeneration (standardized indirect effect: -0.061, 95% confidence interval: -0.089; -0.032), but not mediated by SVD and AD markers. Results were similar when considering latent variables of memory or executive functioning. CONCLUSION: In a large clinical cohort in the elderly, diabetes is associated with lower cognition through neurodegeneration, independently of SVD and AD biomarkers.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enDiabetes Mellitus and Cognition: A Pathway Analysis in the MEMENTO Cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000012440en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34210821en_US
bordeaux.journalNeurologyen_US
bordeaux.pagee836-e848en_US
bordeaux.volume97en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamMEMENTOen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurology&rft.date=2021-07-01&rft.volume=97&rft.issue=8&rft.spage=e836-e848&rft.epage=e836-e848&rft.eissn=0028-3878&rft.issn=0028-3878&rft.au=FRISON,%20Eric&PROUST-LIMA,%20Cecile&MANGIN,%20Jean-Francois&HABERT,%20Marie-Odile&BOMBOIS,%20Stephanie&rft.genre=article


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