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dc.rights.licenseopenen_US
dc.contributor.authorTABONE, Marie-Dominique
dc.contributor.authorKOLTA, Sami
dc.contributor.authorAUQUIER, Pascal
dc.contributor.authorVERCASSON, Camille
dc.contributor.authorCHASTAGNER, Pascal
dc.contributor.authorKANOLD, Justyna
dc.contributor.authorROHRLICH, Pierre-Simon
dc.contributor.authorBERTRAND, Yves
dc.contributor.authorBARUCHEL, Andre
dc.contributor.authorPLANTAZ, Dominique
dc.contributor.authorGANDEMER, Virginie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUCASSOU, Stephane
dc.contributor.authorPETIT, Arnaud
dc.contributor.authorPAILLARD, Catherine
dc.contributor.authorLEVERGER, Guy
dc.contributor.authorDALLE, Jean-Hugues
dc.contributor.authorBERBIS, Julie
dc.contributor.authorROUX, Christian
dc.contributor.authorMICHEL, Gerard
dc.date.accessioned2021-08-24T09:46:14Z
dc.date.available2021-08-24T09:46:14Z
dc.date.issued2021-02
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110203
dc.description.abstractEnThis prospective study aimed to analyze determinants that can influence bone mineral density evolution in childhood acute leukemia survivors. Patients included were selected from the long-term follow-up LEA cohort and had dual energy radiograph absorptiometry scan between 10 and 18 years and after the age of 18. All scans were centrally reviewed. Bone mineral density was measured at the lumbar spine, femoral neck, total hip, and whole body, and expressed as z-score. Eighty-nine patients (female 39, lymphoblastic leukemia 68, relapse 25, hematopoietic stem cell transplantation 44, and mean age 15.4 and 20.1 years at the first and second scans, respectively) were studied. The first and second scan z-scores were significantly correlated (P < 10(-3)). Mean femoral neck and total hip z-scores improved significantly between the first and second scans, whereas no significant evolution occurred at the lumbar spine and whole-body level. On the second evaluation, 14.6% of patients had z-score <-2 at the lumbar spine and 4.3% at the femoral neck level. Gender, type of leukemia, transplantation, relapse, cumulative corticosteroid doses, or growth hormone deficiency did not have any significant impact on z-score variation. Younger age at diagnosis (<= 8.5 years) proved an unfavorable risk factor for z-score evolution at the lumbar spine (P = 0.041); the trend did not reach statistical significance for metabolic syndrome (P = 0.054). At the femoral neck, both were associated with unfavorable z-score evolution (P = 0.003 and 0.025, respectively). Patients treated at a younger age and those with metabolic syndrome seem to be at higher risk of bone mineral density decline and should benefit from specific interventions.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enBone Mineral Density Evolution and Its Determinants in Long-term Survivors of Childhood Acute Leukemia A Leucemies Enfants Adolescents Study
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/hs9.0000000000000518en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33458594en_US
bordeaux.journalHemaSphereen_US
bordeaux.pagee518en_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National Du Canceren_US
bordeaux.identifier.funderIDAssociation Laurette Fugainen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDLigue Contre le Canceren_US
bordeaux.identifier.funderIDCanceropôle PACAen_US
bordeaux.identifier.funderIDConseil Régional Provence-Alpes-Côte d'Azuren_US
bordeaux.identifier.funderIDLes 111 des Artsen_US
bordeaux.identifier.funderIDInstitut pour la Recherche en Santé Publiqueen_US
hal.identifierhal-03325042
hal.version1
hal.date.transferred2021-08-24T09:46:21Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=HemaSphere&amp;rft.date=2021-02&amp;rft.volume=5&amp;rft.issue=2&amp;rft.spage=e518&amp;rft.epage=e518&amp;rft.au=TABONE,%20Marie-Dominique&amp;KOLTA,%20Sami&amp;AUQUIER,%20Pascal&amp;VERCASSON,%20Camille&amp;CHASTAGNER,%20Pascal&amp;rft.genre=article


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