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Prevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSOUMARE, Aicha
dc.contributor.authorBEGUEDOU, Naka
dc.contributor.authorLAURENT, Alexandre
dc.contributor.authorBROCHET, Bruno
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBORDES, Constance
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOURNET, Sandy
dc.contributor.authorMELLET, Emmanuel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPEREIRA, Edwige
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPOLLET, Clothilde
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLACHAIZE-GABOREAU, Morgane
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOUGIN, Marie
dc.contributor.authorTSUCHIDA, Ami
dc.contributor.authorLOISEAU, Hugues
dc.contributor.authorTOURDIAS, Thomas
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorMAZOYER, Bernard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.date.accessioned2021-08-24T09:26:11Z
dc.date.available2021-08-24T09:26:11Z
dc.date.issued2021-05-20
dc.identifier.issn1664-2295 (Print) 1664-2295en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110201
dc.description.abstractEnBackground and Objectives: Young adults represent an increasingly large proportion of healthy volunteers in brain imaging research, but descriptions of incidental findings (IFs) in this age group are scarce. We aimed to assess the prevalence and severity of IFs on brain MRIs of healthy young research participants aged 18-35 years, and to describe the protocol implemented to handle them. Methods: The study population comprised 1,867 participants aged 22.1 ± 2.3 years (72% women) from MRi-Share, the cross-sectional brain MRI substudy of the i-Share student cohort. IFs were flagged during the MRI quality control. We estimated the proportion of participants with IFs [any, requiring medical referral, potentially serious (PSIFs) as defined in the UK biobank]: overall, by type and severity of the final diagnosis, as well as the number of IFs. Results: 78/1,867 participants had at least one IF [4.2%, 95% Confidence Interval (CI) 3.4-5.2%]. IFs requiring medical referral (n = 38) were observed in 36/1,867 participants (1.9%, 1.4-2.7%), and represented 47.5% of the 80 IFs initially flagged. Referred IFs were retrospectively classified as PSIFs in 25/1,867 participants (1.3%, 0.9-2.0%), accounting for 68.4% of anomalies referred (26/38). The most common final diagnosis was cysts or ventricular abnormalities in all participants (9/1,867; 0.5%, 0.2-0.9%) and in those with referred IFs (9/36; 25.0%, 13.6-41.3%), while it was multiple sclerosis or radiologically isolated syndrome in participants with PSIFs (5/19; 26.3%, 11.5-49.1%) who represented 0.1% (0.0-0.4%) and 0.2% (0.03-0.5%) of all participants, respectively. Final diagnoses were considered serious in 11/1,867 participants (0.6%, 0.3-1.1%). Among participants with referred IFs, 13.9% (5/36) required active intervention, while 50.0% (18/36) were put on clinical surveillance. Conclusions: In a large brain imaging study of young healthy adults participating in research we observed a non-negligible frequency of IFs. The etiological pattern differed from what has been described in older adults.
dc.description.sponsorshipProgramme d'investissements - Idex Bordeaux - LAPHIA - ANR-10-IDEX-0302en_US
dc.description.sponsorshipStopping cognitive decline and dementia by fighting covert cerebral small vessel diseaseen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enIncidental findings
dc.subject.enBrain MRI
dc.subject.enPrevalence
dc.subject.enYoung adults
dc.subject.enEpidemiology
dc.subject.enMultiple sclerosis
dc.subject.enRadiologically isolated syndrome
dc.title.enPrevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fneur.2021.675244en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34093421en_US
dc.description.sponsorshipEuropeInvestissement d'aveniren_US
bordeaux.journalFrontiers in Neurologyen_US
bordeaux.page675244en_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPH
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDH2020 European Research Councilen_US
bordeaux.identifier.funderIDEuropean Research Councilen_US
hal.identifierhal-03324980
hal.version1
hal.date.transferred2021-08-24T09:26:17Z
hal.exporttrue
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