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Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

dc.rights.licenseopenen_US
dc.contributor.authorDE ROJAS, Itziar
dc.contributor.authorMORENO-GRAU, Sonia
dc.contributor.authorTESI, Niccolo
dc.contributor.authorGRENIER-BOLEY, Benjamin
dc.contributor.authorANDRADE, Victor
dc.contributor.authorJANSEN, Iris E.
dc.contributor.authorPEDERSEN, Nancy L.
dc.contributor.authorSTRINGA, Najada
dc.contributor.authorZETTERGREN, Anna
dc.contributor.authorHERNANDEZ, Isabel
dc.contributor.authorMONTRREAL, Laura
dc.contributor.authorANTUNEZ, Carmen
dc.contributor.authorANTONELL, Anna
dc.contributor.authorTANKARD, Rick M.
dc.contributor.authorBIS, Joshua C.
dc.contributor.authorSIMS, Rebecca
dc.contributor.authorBELLENGUEZ, Celine
dc.contributor.authorQUINTELA, Ines
dc.contributor.authorGONZALEZ-PEREZ, Antonio
dc.contributor.authorCALERO, Miguel
dc.contributor.authorFRANCO-MACIAS, Emilio
dc.contributor.authorMACIAS, Juan
dc.contributor.authorBLESA, Rafael
dc.contributor.authorCERVERA-CARLES, Laura
dc.contributor.authorMENENDEZ-GONZALEZ, Manuel
dc.contributor.authorFRANK-GARCIA, Ana
dc.contributor.authorROYO, Jose Luis
dc.contributor.authorMORENO, Fermin
dc.contributor.authorHUERTO VILAS, Raquel
dc.contributor.authorBAQUERO, Miquel
dc.contributor.authorDIEZ-FAIREN, Monica
dc.contributor.authorLAGE, Carmen
dc.contributor.authorGARCIA-MADRONA, Sebastian
dc.contributor.authorGARCIA-GONZALEZ, Pablo
dc.contributor.authorALARCON-MARTIN, Emilio
dc.contributor.authorVALERO, Sergi
dc.contributor.authorSOTOLONGO-GRAU, Oscar
dc.contributor.authorULLGREN, Abbe
dc.contributor.authorNAJ, Adam C.
dc.contributor.authorLEMSTRA, Afina W.
dc.contributor.authorBENAQUE, Alba
dc.contributor.authorPEREZ-CORDON, Alba
dc.contributor.authorBENUSSI, Alberto
dc.contributor.authorRABANO, Alberto
dc.contributor.authorPADOVANI, Alessandro
dc.contributor.authorSQUASSINA, Alessio
dc.contributor.authorDE MENDONCA, Alexandre
dc.contributor.authorARIAS PASTOR, Alfonso
dc.contributor.authorKOK, Almar A. L.
dc.contributor.authorMEGGY, Alun
dc.contributor.authorPASTOR, Ana Belen
dc.contributor.authorESPINOSA, Ana
dc.contributor.authorCORMA-GOMEZ, Anais
dc.contributor.authorMARTIN MONTES, Angel
dc.contributor.authorSANABRIA, Angela
dc.contributor.authorDESTEFANO, Anita L.
dc.contributor.authorSCHNEIDER, Anja
dc.contributor.authorHAAPASALO, Annakaisa
dc.contributor.authorKINHULT STAHLBOM, Anne
dc.contributor.authorTYBJAERG-HANSEN, Anne
dc.contributor.authorHARTMANN, Annette M.
dc.contributor.authorSPOTTKE, Annika
dc.contributor.authorCORBATON-ANCHUELO, Arturo
dc.contributor.authorRONGVE, Arvid
dc.contributor.authorBORRONI, Barbara
dc.contributor.authorAROSIO, Beatrice
dc.contributor.authorNACMIAS, Benedetta
dc.contributor.authorNORDESTGAARD, Borge G.
dc.contributor.authorKUNKLE, Brian W.
dc.contributor.authorCHARBONNIER, Camille
dc.contributor.authorABDELNOUR, Carla
dc.contributor.authorMASULLO, Carlo
dc.contributor.authorMARTINEZ RODRIGUEZ, Carmen
dc.contributor.authorMUNOZ-FERNANDEZ, Carmen
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorGRAFF, Caroline
dc.contributor.authorFERREIRA, Catarina B.
dc.contributor.authorCHILLOTTI, Caterina
dc.contributor.authorREYNOLDS, Chandra A.
dc.contributor.authorFENOGLIO, Chiara
dc.contributor.authorVAN BROECKHOVEN, Christine
dc.contributor.authorCLARK, Christopher
dc.contributor.authorPISANU, Claudia
dc.contributor.authorSATIZABAL, Claudia L.
dc.contributor.authorHOLMES, Clive
dc.contributor.authorBUIZA-RUEDA, Dolores
dc.contributor.authorAARSLAND, Dag
dc.contributor.authorRUJESCU, Dan
dc.contributor.authorALCOLEA, Daniel
dc.contributor.authorGALIMBERTI, Daniela
dc.contributor.authorWALLON, David
dc.contributor.authorSERIPA, Davide
dc.contributor.authorGRUNBLATT, Edna
dc.contributor.authorDARDIOTIS, Efthimios
dc.contributor.authorDUZEL, Emrah
dc.contributor.authorSCARPINI, Elio
dc.contributor.authorCONTI, Elisa
dc.contributor.authorRUBINO, Elisa
dc.contributor.authorGELPI, Ellen
dc.contributor.authorRODRIGUEZ-RODRIGUEZ, Eloy
dc.contributor.authorDURON, Emmanuelle
dc.contributor.authorBOERWINKLE, Eric
dc.contributor.authorFERRI, Evelyn
dc.contributor.authorTAGLIAVINI, Fabrizio
dc.contributor.authorKUCUKALI, Fahri
dc.contributor.authorPASQUIER, Florence
dc.contributor.authorSANCHEZ-GARCIA, Florentino
dc.contributor.authorMANGIALASCHE, Francesca
dc.contributor.authorJESSEN, Frank
dc.contributor.authorNICOLAS, Gael
dc.contributor.authorSELBAEK, Geir
dc.contributor.authorORTEGA, Gemma
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
dc.contributor.authorHADJIGEORGIOU, Georgios
dc.contributor.authorROSSI, Giacomina
dc.contributor.authorSPALLETTA, Gianfranco
dc.contributor.authorGIACCONE, Giorgio
dc.contributor.authorGRANDE, Giulia
dc.contributor.authorBINETTI, Giuliano
dc.contributor.authorPAPENBERG, Goran
dc.contributor.authorHAMPEL, Harald
dc.contributor.authorBAILLY, Henri
dc.contributor.authorZETTERBERG, Henrik
dc.contributor.authorSOININEN, Hilkka
dc.contributor.authorKARLSSON, Ida K.
dc.contributor.authorALVAREZ, Ignacio
dc.contributor.authorAPPOLLONIO, Ildebrando
dc.contributor.authorGIEGLING, Ina
dc.contributor.authorSKOOG, Ingmar
dc.contributor.authorSALTVEDT, Ingvild
dc.contributor.authorRAINERO, Innocenzo
dc.contributor.authorROSAS ALLENDE, Irene
dc.contributor.authorHORT, Jakub
dc.contributor.authorDIEHL-SCHMID, Janine
dc.contributor.authorVAN DONGEN, Jasper
dc.contributor.authorVIDAL, Jean-Sebastien
dc.contributor.authorLEHTISALO, Jenni
dc.contributor.authorWILTFANG, Jens
dc.contributor.authorTHOMASSEN, Jesper Qvist
dc.contributor.authorKORNHUBER, Johannes
dc.contributor.authorHAINES, Jonathan L.
dc.contributor.authorVOGELGSANG, Jonathan
dc.contributor.authorPINEDA, Juan A.
dc.contributor.authorFORTEA, Juan
dc.contributor.authorPOPP, Julius
dc.contributor.authorDECKERT, Jurgen
dc.contributor.authorBUERGER, Katharina
dc.contributor.authorMORGAN, Kevin
dc.contributor.authorFLIESSBACH, Klaus
dc.contributor.authorSLEEGERS, Kristel
dc.contributor.authorMOLINA-PORCEL, Laura
dc.contributor.authorKILANDER, Lena
dc.contributor.authorWEINHOLD, Leonie
dc.contributor.authorFARRER, Lindsay A.
dc.contributor.authorWANG, Li-San
dc.contributor.authorKLEINEIDAM, Luca
dc.contributor.authorFAROTTI, Lucia
dc.contributor.authorPARNETTI, Lucilla
dc.contributor.authorTREMOLIZZO, Lucio
dc.contributor.authorHAUSNER, Lucrezia
dc.contributor.authorBENUSSI, Luisa
dc.contributor.authorFROELICH, Lutz
dc.contributor.authorIKRAM, M. Arfan
dc.contributor.authorDENIZ-NARANJO, M. Candida
dc.contributor.authorTSOLAKI, Magda
dc.contributor.authorROSENDE-ROCA, Maitee
dc.contributor.authorLOWENMARK, Malin
dc.contributor.authorHULSMAN, Marc
dc.contributor.authorSPALLAZZI, Marco
dc.contributor.authorPERICAK-VANCE, Margaret A.
dc.contributor.authorESIRI, Margaret
dc.contributor.authorBERNAL SANCHEZ-ARJONA, Maria
dc.contributor.authorDALMASSO, Maria Carolina
dc.contributor.authorMARTINEZ-LARRAD, Maria Teresa
dc.contributor.authorARCARO, Marina
dc.contributor.authorNOTHEN, Markus M.
dc.contributor.authorFERNANDEZ-FUERTES, Marta
dc.contributor.authorDICHGANS, Martin
dc.contributor.authorINGELSSON, Martin
dc.contributor.authorHERRMANN, Martin J.
dc.contributor.authorSCHERER, Martin
dc.contributor.authorVYHNALEK, Martin
dc.contributor.authorKOSMIDIS, Mary H.
dc.contributor.authorYANNAKOULIA, Mary
dc.contributor.authorSCHMID, Matthias
dc.contributor.authorEWERS, Michael
dc.contributor.authorHENEKA, Michael T.
dc.contributor.authorWAGNER, Michael
dc.contributor.authorSCAMOSCI, Michela
dc.contributor.authorKIVIPELTO, Miia
dc.contributor.authorHILTUNEN, Mikko
dc.contributor.authorZULAICA, Miren
dc.contributor.authorALEGRET, Montserrat
dc.contributor.authorFORNAGE, Myriam
dc.contributor.authorROBERTO, Natalia
dc.contributor.authorVAN SCHOOR, Natasja M.
dc.contributor.authorSEIDU, Nazib M.
dc.contributor.authorBANAJ, Nerisa
dc.contributor.authorARMSTRONG, Nicola J.
dc.contributor.authorSCARMEAS, Nikolaos
dc.contributor.authorSCHERBAUM, Norbert
dc.contributor.authorGOLDHARDT, Oliver
dc.contributor.authorHANON, Oliver
dc.contributor.authorPETERS, Oliver
dc.contributor.authorSKROBOT, Olivia Anna
dc.contributor.authorQUENEZ, Olivier
dc.contributor.authorLERCH, Ondrej
dc.contributor.authorBOSSU, Paola
dc.contributor.authorCAFFARRA, Paolo
dc.contributor.authorDIONIGI ROSSI, Paolo
dc.contributor.authorSAKKA, Paraskevi
dc.contributor.authorHOFFMANN, Per
dc.contributor.authorHOLMANS, Peter A.
dc.contributor.authorFISCHER, Peter
dc.contributor.authorRIEDERER, Peter
dc.contributor.authorYANG, Qiong
dc.contributor.authorMARSHALL, Rachel
dc.contributor.authorKALARIA, Rajesh N.
dc.contributor.authorMAYEUX, Richard
dc.contributor.authorVANDENBERGHE, Rik
dc.contributor.authorCECCHETTI, Roberta
dc.contributor.authorGHIDONI, Roberta
dc.contributor.authorFRIKKE-SCHMIDT, Ruth
dc.contributor.authorSORBI, Sandro
dc.contributor.authorHAGG, Sara
dc.contributor.authorENGELBORGHS, Sebastiaan
dc.contributor.authorHELISALMI, Seppo
dc.contributor.authorBOTNE SANDO, Sigrid
dc.contributor.authorKERN, Silke
dc.contributor.authorARCHETTI, Silvana
dc.contributor.authorBOSCHI, Silvia
dc.contributor.authorFOSTINELLI, Silvia
dc.contributor.authorGIL, Silvia
dc.contributor.authorMENDOZA, Silvia
dc.contributor.authorMEAD, Simon
dc.contributor.authorCICCONE, Simona
dc.contributor.authorDJUROVIC, Srdjan
dc.contributor.authorHEILMANN-HEIMBACH, Stefanie
dc.contributor.authorRIEDEL-HELLER, Steffi
dc.contributor.authorKUULASMAA, Teemu
dc.contributor.authorDEL SER, Teodoro
dc.contributor.authorLEBOUVIER, Thibaud
dc.contributor.authorPOLAK, Thomas
dc.contributor.authorNGANDU, Tiia
dc.contributor.authorGRIMMER, Timo
dc.contributor.authorBESSI, Valentina
dc.contributor.authorESCOTT-PRICE, Valentina
dc.contributor.authorGIEDRAITIS, Vilmantas
dc.contributor.authorDERAMECOURT, Vincent
dc.contributor.authorMAIER, Wolfgang
dc.contributor.authorJIAN, Xueqiu
dc.contributor.authorPIJNENBURG, Yolande A. L.
dc.contributor.authorCONTRIBUTORS, Eadb
dc.contributor.authorGROUP, Gr Ace Study
dc.contributor.authorCONSORTIUM, Degesco
dc.contributor.authorCONSORTIA, Pgc-Alz
dc.contributor.authorKEHOE, Patrick Gavin
dc.contributor.authorGARCIA-RIBAS, Guillermo
dc.contributor.authorSANCHEZ-JUAN, Pascual
dc.contributor.authorPASTOR, Pau
dc.contributor.authorPEREZ-TUR, Jordi
dc.contributor.authorPINOL-RIPOLL, Gerard
dc.contributor.authorLOPEZ DE MUNAIN, Adolfo
dc.contributor.authorGARCIA-ALBERCA, Jose Maria
dc.contributor.authorBULLIDO, Maria J.
dc.contributor.authorALVAREZ, Victoria
dc.contributor.authorLLEO, Alberto
dc.contributor.authorREAL, Luis M.
dc.contributor.authorMIR, Pablo
dc.contributor.authorMEDINA, Miguel
dc.contributor.authorSCHELTENS, Philip
dc.contributor.authorHOLSTEGE, Henne
dc.contributor.authorMARQUIE, Marta
dc.contributor.authorSAEZ, Maria Eugenia
dc.contributor.authorCARRACEDO, Angel
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorSCHELLENBERG, Gerard D.
dc.contributor.authorWILLIAMS, Julie
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorVAN DUIJN, Cornelia M.
dc.contributor.authorMATHER, Karen A.
dc.contributor.authorSANCHEZ-VALLE, Raquel
dc.contributor.authorSERRANO-RIOS, Manuel
dc.contributor.authorORELLANA, Adelina
dc.contributor.authorTARRAGA, Lluis
dc.contributor.authorBLENNOW, Kaj
dc.contributor.authorHUISMAN, Martijn
dc.contributor.authorANDREASSEN, Ole A.
dc.contributor.authorPOSTHUMA, Danielle
dc.contributor.authorCLARIMON, Jordi
dc.contributor.authorBOADA, Merce
dc.contributor.authorVAN DER FLIER, Wiesje M.
dc.contributor.authorRAMIREZ, Alfredo
dc.contributor.authorLAMBERT, Jean-Charles
dc.contributor.authorVAN DER LEE, Sven J.
dc.contributor.authorRUIZ, Agustin
dc.date.accessioned2021-07-15T13:03:38Z
dc.date.available2021-07-15T13:03:38Z
dc.date.issued2021-06-07
dc.identifier.issn2041-1723 (Electronic) 2041-1723 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/109261
dc.description.abstractEnGenetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCognitive ageing
dc.subject.enGenomics
dc.subject.enRisk factors
dc.title.enCommon variants in Alzheimer's disease and risk stratification by polygenic risk scores
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-021-22491-8en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34099642en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page3417en_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamCIC1401en_US
bordeaux.teamMORPH3Eusen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03287265
hal.version1
hal.date.transferred2021-07-15T13:04:06Z
hal.exporttrue
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