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Dopamine transporter imaging for the diagnosis of multiple system atrophy cerebellar type

dc.rights.licenseopenen_US
dc.contributor.authorVERGNET, S.
dc.contributor.authorHIVES, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFOUBERT-SAMIER, Alexandra
dc.contributor.authorPAYOUX, P.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorFERNANDEZ, Philippe
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMEYER, Marie
dc.contributor.authorDUPOUY, J.
dc.contributor.authorBREFEL-COURBON, C.
dc.contributor.authorORY-MAGNE, F.
dc.contributor.authorRASCOL, O.
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTISON, Francois
dc.contributor.authorPAVY-LE TRAON, A.
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorMEISSNER, Wassilios
IDREF: 113664761
dc.date.accessioned2020-07-16T13:25:03Z
dc.date.available2020-07-16T13:25:03Z
dc.date.issued2019-06
dc.identifier.issn1873-5126 (Electronic) 1353-8020 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10500
dc.description.abstractEnINTRODUCTION: The added value of dopamine transporter SPECT (DAT-SPECT) for the diagnosis of "possible" multiple system atrophy of the cerebellar type (MSA-C) remains unknown. METHODS: We reviewed retrospectively the charts of 128 consecutive patients with a clinical diagnosis of MSA-C who were seen between 2007 and 2016 at the French Reference Center for MSA. The main objective was to evaluate the proportion of patients for whom the diagnosis of "possible" MSA-C was made because of a positive DAT-SPECT. RESULTS: Seventy-eight MSA-C patients had at least one DAT-SPECT. Fifty-nine of them were considered for the final analysis. In these, 22 had "possible" MSA-C and 23 "probable" MSA-C before DAT-SPECT, while 14 did not reach diagnosis criteria at that time. In those with "possible" MSA-C, DAT-SPECT was positive in 64%. In patients with "probable" MSA-C, 83% showed nigrostriatal denervation. Six out of 14 (43%) received a diagnosis of "possible" MSA-C because of positive DAT-SPECT. These patients had mean disease duration of 2.3 years at the time of DAT-SPECT compared to 3.5 years of the entire cohort of MSA-C patients with DAT-SPECT. Of the eight remaining, one had positive DAT-SPECT but also pons atrophy on magnetic resonance imaging, and seven progressed to "probable" MSA based on clinical features. CONCLUSION: Our results suggest that DAT-SPECT significantly contributes to the diagnosis of "possible" MSA-C (43% of patients not reaching consensus diagnosis criteria before DAT-SPECT). DAT-SPECT seems especially useful in patients with shorter disease duration, while a negative result does not exclude a diagnosis of MSA.
dc.language.isoENen_US
dc.subject.enSEPIA
dc.title.enDopamine transporter imaging for the diagnosis of multiple system atrophy cerebellar type
dc.title.alternativeParkinsonism Relat Disorden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.parkreldis.2019.02.006en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30745212en_US
bordeaux.journalParkinsonism & Related Disordersen_US
bordeaux.page199-203en_US
bordeaux.volume63en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03163693
hal.version1
hal.date.transferred2021-03-09T13:11:22Z
hal.exporttrue
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