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Multi-trajectories of antidepressant and antipsychotic use: a 11-year naturalistic study in a community-based sample

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVERDOUX, Helene
IDREF: 115951903
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPAMBRUN, Elodie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDAUBECH-TOURNIER, Marie
dc.contributor.authorCORTAREDONA, Sebastien
dc.contributor.authorVERGER, P.
dc.date.accessioned2020-07-16T13:08:51Z
dc.date.available2020-07-16T13:08:51Z
dc.date.issued2019-06
dc.identifier.issn1600-0447 (Electronic) 0001-690X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10496
dc.description.abstractEnOBJECTIVE: To explore the temporal dynamic of antidepressant and antipsychotic co-prescribing in real-life conditions. METHODS: The study was performed using reimbursement data from the French Insurance Healthcare system in a cohort of 118,454 persons with at least one dispensing of antidepressants and/or antipsychotics over the period 2006-2016. Latent class analyses were used to identify homogeneous groups of persons following similar multi-trajectories of antidepressant and/or antipsychotic dispensing. Multivariate polynomial logistic regression models were used to explore the characteristics independently associated with distinct trajectories. RESULTS: Five multi-trajectories of antidepressant and/or antipsychotic dispensing were identified: more than half of the sample (58%) had very low antidepressant and antipsychotic use; two groups had chronic (12%) or decreasing (11%) antidepressant use with very low antipsychotic use; two groups used both antidepressants and antipsychotics simultaneously either in an increasing (12%) or chronic (7%) way. Persons with chronic antidepressant-antipsychotic use presented with markers of poor social and mental health conditions. CONCLUSIONS: Most persons using antipsychotics over the follow-up also used antidepressants over the same period. The benefit/risk ratio of these prescribing practices should be further explored as the long-term efficacy of antidepressant-antipsychotic polypharmacy is poorly documented, while this combination increases the risk of adverse effects. This article is protected by copyright. All rights reserved.
dc.language.isoENen_US
dc.subject.enPharmacoEpi-Drugs
dc.title.enMulti-trajectories of antidepressant and antipsychotic use: a 11-year naturalistic study in a community-based sample
dc.title.alternativeActa Psychiatr Scanden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/acps.13020en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30844084en_US
bordeaux.journalActa psychiatrica Scandinavicaen_US
bordeaux.page536-547en_US
bordeaux.volume139en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta%20psychiatrica%20Scandinavica&rft.date=2019-06&rft.volume=139&rft.issue=6&rft.spage=536-547&rft.epage=536-547&rft.eissn=1600-0447%20(Electronic)%200001-690X%20(Linking)&rft.issn=1600-0447%20(Electronic)%200001-690X%20(Linking)&rft.au=VERDOUX,%20Helene&PAMBRUN,%20Elodie&DAUBECH-TOURNIER,%20Marie&CORTAREDONA,%20Sebastien&VERGER,%20P.&rft.genre=article


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