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Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)

dc.rights.licenseopenen_US
dc.contributor.authorTRIEBNER, K.
dc.contributor.authorACCORDINI, S.
dc.contributor.authorCALCIANO, L.
dc.contributor.authorJOHANNESSEN, A.
dc.contributor.authorBENEDIKTSDOTTIR, B.
dc.contributor.authorBIFULCO, E.
dc.contributor.authorDEMOLY, P.
dc.contributor.authorDHARMAGE, S. C.
dc.contributor.authorFRANKLIN, K. A.
dc.contributor.authorGARCIA-AYMERICH, J.
dc.contributor.authorGULLON BLANCO, J. A.
dc.contributor.authorHEINRICH, J.
dc.contributor.authorHOLM, M.
dc.contributor.authorJARVIS, D.
dc.contributor.authorJOGI, R.
dc.contributor.authorLINDBERG, E.
dc.contributor.authorMARTINEZ-MORATALLA, J.
dc.contributor.authorMUNIOZGUREN AGIRRE, N.
dc.contributor.authorPIN, I.
dc.contributor.authorPROBST-HENSCH, N.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorSANCHEZ-RAMOS, J. L.
dc.contributor.authorSCHLUNSSEN, V.
dc.contributor.authorSVANES, C.
dc.contributor.authorHUSTAD, S.
dc.contributor.authorLEYNAERT, B.
dc.contributor.authorGOMEZ REAL, F.
dc.date.accessioned2020-07-15T15:14:16Z
dc.date.available2020-07-15T15:14:16Z
dc.date.issued2019-02
dc.identifier.issn0378-5122en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10482
dc.description.abstractEnOBJECTIVES: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes. STUDY DESIGN: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. MAIN OUTCOME MEASURES: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). RESULTS: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years. CONCLUSIONS: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.enEPICENE
dc.title.enExogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)
dc.title.alternativeMaturitasen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.maturitas.2018.11.007en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30583761en_US
bordeaux.journalMaturitasen_US
bordeaux.page29-34en_US
bordeaux.volume120en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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