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Increased liver stiffness is associated with mortality in HIV/HCV coinfected subjects: The French nationwide ANRS CO13 HEPAVIH cohort study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSHILI-MASMOUDI, Sarah
dc.contributor.authorSOGNI, P.
dc.contributor.authorDE LEDINGHEN, V.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorESTERLE, Laure
dc.contributor.authorVALANTIN, M. A.
dc.contributor.authorPOIZOT-MARTIN, I.
dc.contributor.authorSIMON, A.
dc.contributor.authorROSENTHAL, E.
dc.contributor.authorLACOMBE, K.
dc.contributor.authorPIALOUX, G.
dc.contributor.authorBOUCHAUD, O.
dc.contributor.authorGERVAIS-HASENKNOFF, A.
dc.contributor.authorGOUJARD, C.
dc.contributor.authorPIROTH, L.
dc.contributor.authorZUCMAN, D.
dc.contributor.authorDOMINGUEZ, S.
dc.contributor.authorRAFFI, F.
dc.contributor.authorALRIC, L.
dc.contributor.authorBANI-SADR, F.
dc.contributor.authorLASCOUX-COMBE, C.
dc.contributor.authorGARIPUY, D.
dc.contributor.authorMIAILHES, P.
dc.contributor.authorVITTECOQ, D.
dc.contributor.authorDUVIVIER, C.
dc.contributor.authorAUMAITRE, H.
dc.contributor.authorNEAU, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMORLAT, Philippe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDABIS, Francois
dc.contributor.authorSALMON, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.date.accessioned2020-07-13T12:50:51Z
dc.date.available2020-07-13T12:50:51Z
dc.date.issued2019-01-25
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10440
dc.description.abstractEnBACKGROUND: The association between liver stiffness measurements (LSM) and mortality has not been fully described. In particular the effect of LSM on all-cause mortality taking sustained virological response (SVR) into account needs further study. METHODS: HIV/HCV participants in the French nation-wide, prospective, multicenter ANRS CO13 HEPAVIH cohort, with >/=1 LSM by FibroScan (FS) and a detectable HCV RNA when the first valid FS was performed were included. Cox proportional hazards models with delayed entry were performed to determine factors associated with all-cause mortality. LSM and SVR were considered as time dependent covariates. RESULTS: 1,062 patients were included from 2005 to 2015 (69.8% men, median age 45.7 years (IQR 42.4-49.1)). 21.7% had baseline LSM >12.5 kPa. Median follow-up was 4.9 years (IQR 3.2-6.1). 727 (68.5%) were ever treated for HCV: 189 of them (26.0%) achieved SVR. 76 deaths were observed (26 liver-related, 10 HIV-related, 29 non-liver-non-HIV-related, 11 of unknown cause). At the age of 50, the mortality rate was 4.5% for patients with LSM </=12.5 kPa and 10.8% for patients with LSM >12.5 kPa. LSM >12.5 kPa (adjusted Hazard Ratio [aHR] = 3.35 [2.06; 5.45], p<0.0001), history of HCV treatment (aHR = 0.53 [0.32; 0.90], p = 0.01) and smoking (past (aHR = 5.69 [1.56; 20.78]) and current (3.22 [0.93; 11.09]) versus never, p = 0.01) were associated with all-cause mortality independently of SVR, age, sex, alcohol use and metabolic disorders. CONCLUSION: Any LSM >12.5 kPa was strongly associated with all-cause mortality independently of SVR and other important covariates. Our results suggest that close follow-up of these patients should remain a priority even after achieving SVR.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subject.enMORPH3Eus
dc.subject.enCIC1401
dc.subject.enFR
dc.subject.enANRS CO13 HEPAVIH
dc.title.enIncreased liver stiffness is associated with mortality in HIV/HCV coinfected subjects: The French nationwide ANRS CO13 HEPAVIH cohort study
dc.title.alternativePLoS Oneen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pone.0211286en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30682180en_US
bordeaux.journalPLoS ONEen_US
bordeaux.pagee0211286en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.exportfalse
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