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Genetic architecture of subcortical brain structures in 38,851 individuals

dc.rights.licenseopenen_US
dc.contributor.authorSATIZABAL, C. L.
dc.contributor.authorADAMS, H. H. H.
dc.contributor.authorHIBAR, D. P.
dc.contributor.authorWHITE, C. C.
dc.contributor.authorKNOL, M. J.
dc.contributor.authorSTEIN, J. L.
dc.contributor.authorSCHOLZ, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSARGURUPREMRAJ, Muralidharan
dc.contributor.authorJAHANSHAD, N.
dc.contributor.authorROSHCHUPKIN, G. V.
dc.contributor.authorSMITH, A. V.
dc.contributor.authorBIS, J. C.
dc.contributor.authorJIAN, X.
dc.contributor.authorLUCIANO, M.
dc.contributor.authorHOFER, E.
dc.contributor.authorTEUMER, A.
dc.contributor.authorVAN DER LEE, S. J.
dc.contributor.authorYANG, J.
dc.contributor.authorYANEK, L. R.
dc.contributor.authorLEE, T. V.
dc.contributor.authorLI, S.
dc.contributor.authorHU, Y.
dc.contributor.authorKOH, J. Y.
dc.contributor.authorEICHER, J. D.
dc.contributor.authorDESRIVIERES, S.
dc.contributor.authorARIAS-VASQUEZ, A.
dc.contributor.authorCHAUHAN, Ganesh
dc.contributor.authorATHANASIU, L.
dc.contributor.authorRENTERIA, M. E.
dc.contributor.authorKIM, S.
dc.contributor.authorHOEHN, D.
dc.contributor.authorARMSTRONG, N. J.
dc.contributor.authorCHEN, Q.
dc.contributor.authorHOLMES, A. J.
dc.contributor.authorDEN BRABER, A.
dc.contributor.authorKLOSZEWSKA, I.
dc.contributor.authorANDERSSON, M.
dc.contributor.authorESPESETH, T.
dc.contributor.authorGRIMM, O.
dc.contributor.authorABRAMOVIC, L.
dc.contributor.authorALHUSAINI, S.
dc.contributor.authorMILANESCHI, Y.
dc.contributor.authorPAPMEYER, M.
dc.contributor.authorAXELSSON, T.
dc.contributor.authorEHRLICH, S.
dc.contributor.authorROIZ-SANTIANEZ, R.
dc.contributor.authorKRAEMER, B.
dc.contributor.authorHABERG, A. K.
dc.contributor.authorJONES, H. J.
dc.contributor.authorPIKE, G. B.
dc.contributor.authorSTEIN, D. J.
dc.contributor.authorSTEVENS, A.
dc.contributor.authorBRALTEN, J.
dc.contributor.authorVERNOOIJ, M. W.
dc.contributor.authorHARRIS, T. B.
dc.contributor.authorFILIPPI, I.
dc.contributor.authorWITTE, A. V.
dc.contributor.authorGUADALUPE, T.
dc.contributor.authorWITTFELD, K.
dc.contributor.authorMOSLEY, T. H.
dc.contributor.authorBECKER, J. T.
dc.contributor.authorDOAN, N. T.
dc.contributor.authorHAGENAARS, S. P.
dc.contributor.authorSABA, Y.
dc.contributor.authorCUELLAR-PARTIDA, G.
dc.contributor.authorAMIN, N.
dc.contributor.authorHILAL, S.
dc.contributor.authorNHO, K.
dc.contributor.authorMIRZA-SCHREIBER, N.
dc.contributor.authorARFANAKIS, K.
dc.contributor.authorBECKER, D. M.
dc.contributor.authorAMES, D.
dc.contributor.authorGOLDMAN, A. L.
dc.contributor.authorLEE, P. H.
dc.contributor.authorBOOMSMA, D. I.
dc.contributor.authorLOVESTONE, S.
dc.contributor.authorGIDDALURU, S.
dc.contributor.authorLE HELLARD, S.
dc.contributor.authorMATTHEISEN, M.
dc.contributor.authorBOHLKEN, M. M.
dc.contributor.authorKASPERAVICIUTE, D.
dc.contributor.authorSCHMAAL, L.
dc.contributor.authorLAWRIE, S. M.
dc.contributor.authorAGARTZ, I.
dc.contributor.authorWALTON, E.
dc.contributor.authorTORDESILLAS-GUTIERREZ, D.
dc.contributor.authorDAVIES, G. E.
dc.contributor.authorSHIN, J.
dc.contributor.authorIPSER, J. C.
dc.contributor.authorVINKE, L. N.
dc.contributor.authorHOOGMAN, M.
dc.contributor.authorJIA, T.
dc.contributor.authorBURKHARDT, R.
dc.contributor.authorKLEIN, M.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCRIVELLO, Fabrice
dc.contributor.authorJANOWITZ, D.
dc.contributor.authorCARMICHAEL, O.
dc.contributor.authorHAUKVIK, U. K.
dc.contributor.authorARIBISALA, B. S.
dc.contributor.authorSCHMIDT, H.
dc.contributor.authorSTRIKE, L. T.
dc.contributor.authorCHENG, C. Y.
dc.contributor.authorRISACHER, S. L.
dc.contributor.authorPUTZ, B.
dc.contributor.authorFLEISCHMAN, D. A.
dc.contributor.authorASSAREH, A. A.
dc.contributor.authorMATTAY, V. S.
dc.contributor.authorBUCKNER, R. L.
dc.contributor.authorMECOCCI, P.
dc.contributor.authorDALE, A. M.
dc.contributor.authorCICHON, S.
dc.contributor.authorBOKS, M. P.
dc.contributor.authorMATARIN, M.
dc.contributor.authorPENNINX, Bwjh
dc.contributor.authorCALHOUN, V. D.
dc.contributor.authorCHAKRAVARTY, M. M.
dc.contributor.authorMARQUAND, A. F.
dc.contributor.authorMACARE, C.
dc.contributor.authorKHARABIAN MASOULEH, S.
dc.contributor.authorOOSTERLAAN, J.
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorHEGENSCHEID, K.
dc.contributor.authorROTTER, J. I.
dc.contributor.authorSCHORK, A. J.
dc.contributor.authorLIEWALD, D. C. M.
dc.contributor.authorDE ZUBICARAY, G. I.
dc.contributor.authorWONG, T. Y.
dc.contributor.authorSHEN, L.
dc.contributor.authorSAMANN, P. G.
dc.contributor.authorBRODATY, H.
dc.contributor.authorROFFMAN, J. L.
dc.contributor.authorDE GEUS, E. J. C.
dc.contributor.authorTSOLAKI, M.
dc.contributor.authorERK, S.
dc.contributor.authorVAN EIJK, K. R.
dc.contributor.authorCAVALLERI, G. L.
dc.contributor.authorVAN DER WEE, N. J. A.
dc.contributor.authorMCINTOSH, A. M.
dc.contributor.authorGOLLUB, R. L.
dc.contributor.authorBULAYEVA, K. B.
dc.contributor.authorBERNARD, M.
dc.contributor.authorRICHARDS, J. S.
dc.contributor.authorHIMALI, J. J.
dc.contributor.authorLOEFFLER, M.
dc.contributor.authorROMMELSE, N.
dc.contributor.authorHOFFMANN, W.
dc.contributor.authorWESTLYE, L. T.
dc.contributor.authorVALDES HERNANDEZ, M. C.
dc.contributor.authorHANSELL, N. K.
dc.contributor.authorVAN ERP, T. G. M.
dc.contributor.authorWOLF, C.
dc.contributor.authorKWOK, J. B. J.
dc.contributor.authorVELLAS, B.
dc.contributor.authorHEINZ, A.
dc.contributor.authorOLDE LOOHUIS, L. M.
dc.contributor.authorDELANTY, N.
dc.contributor.authorHO, B. C.
dc.contributor.authorCHING, C. R. K.
dc.contributor.authorSHUMSKAYA, E.
dc.contributor.authorSINGH, B.
dc.contributor.authorHOFMAN, A.
dc.contributor.authorVAN DER MEER, D.
dc.contributor.authorHOMUTH, G.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorBASTIN, M. E.
dc.contributor.authorMONTGOMERY, G. W.
dc.contributor.authorFOROUD, T. M.
dc.contributor.authorREPPERMUND, S.
dc.contributor.authorHOTTENGA, J. J.
dc.contributor.authorSIMMONS, A.
dc.contributor.authorMEYER-LINDENBERG, A.
dc.contributor.authorCAHN, W.
dc.contributor.authorWHELAN, C. D.
dc.contributor.authorVAN DONKELAAR, M. M. J.
dc.contributor.authorYANG, Q.
dc.contributor.authorHOSTEN, N.
dc.contributor.authorGREEN, R. C.
dc.contributor.authorTHALAMUTHU, A.
dc.contributor.authorMOHNKE, S.
dc.contributor.authorHULSHOFF POL, H. E.
dc.contributor.authorLIN, H.
dc.contributor.authorJACK, C. R., Jr.
dc.contributor.authorSCHOFIELD, P. R.
dc.contributor.authorMUHLEISEN, T. W.
dc.contributor.authorMAILLARD, P.
dc.contributor.authorPOTKIN, S. G.
dc.contributor.authorWEN, W.
dc.contributor.authorFLETCHER, E.
dc.contributor.authorTOGA, A. W.
dc.contributor.authorGRUBER, O.
dc.contributor.authorHUENTELMAN, M.
dc.contributor.authorDAVEY SMITH, G.
dc.contributor.authorLAUNER, L. J.
dc.contributor.authorNYBERG, L.
dc.contributor.authorJONSSON, E. G.
dc.contributor.authorCRESPO-FACORRO, B.
dc.contributor.authorKOEN, N.
dc.contributor.authorGREVE, D. N.
dc.contributor.authorUITTERLINDEN, A. G.
dc.contributor.authorWEINBERGER, D. R.
dc.contributor.authorSTEEN, V. M.
dc.contributor.authorFEDKO, I. O.
dc.contributor.authorGROENEWOLD, N. A.
dc.contributor.authorNIESSEN, W. J.
dc.contributor.authorTORO, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorLONGSTRETH, W. T., Jr.
dc.contributor.authorIKRAM, M. K.
dc.contributor.authorSMOLLER, J. W.
dc.contributor.authorVAN TOL, M. J.
dc.contributor.authorSUSSMANN, J. E.
dc.contributor.authorPAUS, T.
dc.contributor.authorLEMAITRE, H.
dc.contributor.authorSCHROETER, M. L.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMAZOYER, Bernard
dc.contributor.authorANDREASSEN, O. A.
dc.contributor.authorHOLSBOER, F.
dc.contributor.authorDEPONDT, C.
dc.contributor.authorVELTMAN, D. J.
dc.contributor.authorTURNER, J. A.
dc.contributor.authorPAUSOVA, Z.
dc.contributor.authorSCHUMANN, G.
dc.contributor.authorVAN ROOIJ, D.
dc.contributor.authorDJUROVIC, S.
dc.contributor.authorDEARY, I. J.
dc.contributor.authorMCMAHON, K. L.
dc.contributor.authorMULLER-MYHSOK, B.
dc.contributor.authorBROUWER, R. M.
dc.contributor.authorSOININEN, H.
dc.contributor.authorPANDOLFO, M.
dc.contributor.authorWASSINK, T. H.
dc.contributor.authorCHEUNG, J. W.
dc.contributor.authorWOLFERS, T.
dc.contributor.authorMARTINOT, J. L.
dc.contributor.authorZWIERS, M. P.
dc.contributor.authorNAUCK, M.
dc.contributor.authorMELLE, I.
dc.contributor.authorMARTIN, N. G.
dc.contributor.authorKANAI, R.
dc.contributor.authorWESTMAN, E.
dc.contributor.authorKAHN, R. S.
dc.contributor.authorSISODIYA, S. M.
dc.contributor.authorWHITE, T.
dc.contributor.authorSAREMI, A.
dc.contributor.authorVAN BOKHOVEN, H.
dc.contributor.authorBRUNNER, H. G.
dc.contributor.authorVOLZKE, H.
dc.contributor.authorWRIGHT, M. J.
dc.contributor.authorVAN 'T ENT, D.
dc.contributor.authorNOTHEN, M. M.
dc.contributor.authorOPHOFF, R. A.
dc.contributor.authorBUITELAAR, J. K.
dc.contributor.authorFERNANDEZ, G.
dc.contributor.authorSACHDEV, P. S.
dc.contributor.authorRIETSCHEL, M.
dc.contributor.authorVAN HAREN, N. E. M.
dc.contributor.authorFISHER, S. E.
dc.contributor.authorBEISER, A. S.
dc.contributor.authorFRANCKS, C.
dc.contributor.authorSAYKIN, A. J.
dc.contributor.authorMATHER, K. A.
dc.contributor.authorROMANCZUK-SEIFERTH, N.
dc.contributor.authorHARTMAN, C. A.
dc.contributor.authorDESTEFANO, A. L.
dc.contributor.authorHESLENFELD, D. J.
dc.contributor.authorWEINER, M. W.
dc.contributor.authorWALTER, H.
dc.contributor.authorHOEKSTRA, P. J.
dc.contributor.authorNYQUIST, P. A.
dc.contributor.authorFRANKE, B.
dc.contributor.authorBENNETT, D. A.
dc.contributor.authorGRABE, H. J.
dc.contributor.authorJOHNSON, A. D.
dc.contributor.authorCHEN, C.
dc.contributor.authorVAN DUIJN, C. M.
dc.contributor.authorLOPEZ, O. L.
dc.contributor.authorFORNAGE, M.
dc.contributor.authorWARDLAW, J. M.
dc.contributor.authorSCHMIDT, R.
dc.contributor.authorDECARLI, C.
dc.contributor.authorDE JAGER, P. L.
dc.contributor.authorVILLRINGER, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorGUDNASON, V.
dc.contributor.authorMEDLAND, S. E.
dc.contributor.authorSHULMAN, J. M.
dc.contributor.authorTHOMPSON, P. M.
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorIKRAM, M. A.
dc.date.accessioned2020-07-13T12:12:29Z
dc.date.available2020-07-13T12:12:29Z
dc.date.issued2019-11
dc.identifier.issn1546-1718 (Electronic) 1061-4036 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10434
dc.description.abstractEnSubcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
dc.language.isoENen_US
dc.subject.enHEALTHY
dc.subject.enVINTAGE
dc.title.enGenetic architecture of subcortical brain structures in 38,851 individuals
dc.title.alternativeNat Geneten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-019-0511-yen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31636452en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page1624-1636en_US
bordeaux.volume51en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPH
bordeaux.teamVINTAGE
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03163768
hal.version1
hal.date.transferred2021-03-09T13:32:05Z
hal.exporttrue
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