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Immune thrombotic thrombocytopenic purpura in older patients: prognosis and long-term survival
dc.rights.license | open | en_US |
dc.contributor.author | PREVEL, R. | |
dc.contributor.author | ROUBAUD-BAUDRON, C. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | GOURLAIN, Samuel | |
dc.contributor.author | JAMME, M. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | PERES, Karine | |
dc.contributor.author | BENHAMOU, Y. | |
dc.contributor.author | GALICIER, L. | |
dc.contributor.author | AZOULAY, E. | |
dc.contributor.author | POULLIN, P. | |
dc.contributor.author | PROVOT, F. | |
dc.contributor.author | MAURY, E. | |
dc.contributor.author | PRESNE, C. | |
dc.contributor.author | HAMIDOU, M. | |
dc.contributor.author | SAHEB, S. | |
dc.contributor.author | WYNCKEL, A. | |
dc.contributor.author | SERVAIS, A. | |
dc.contributor.author | GIRAULT, S. | |
dc.contributor.author | DELMAS, Y. | |
dc.contributor.author | CHATELET, V. | |
dc.contributor.author | AUGUSTO, J. F. | |
dc.contributor.author | MOUSSON, C. | |
dc.contributor.author | PEREZ, P. | |
dc.contributor.author | HALIMI, J. M. | |
dc.contributor.author | KANOUNI, T. | |
dc.contributor.author | LAUTRETTE, A. | |
dc.contributor.author | CHARVET-RUMPLER, A. | |
dc.contributor.author | DELIGNY, C. | |
dc.contributor.author | CHAUVEAU, D. | |
dc.contributor.author | VEYRADIER, A. | |
dc.contributor.author | COPPO, P. | |
dc.date.accessioned | 2020-07-10T06:20:24Z | |
dc.date.available | 2020-07-10T06:20:24Z | |
dc.date.issued | 2019-12-12 | |
dc.identifier.issn | 1528-0020 (Electronic) 0006-4971 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10386 | |
dc.description.abstractEn | Older age is associated with increased mortality in immune thrombotic thrombocytopenic purpura (iTTP). Yet, data are scarce regarding iTTP occurring among older patients. To assess clinical features and long-term impact of iTTP on mortality in older patients (>60 years old), characteristics and prognoses of adult iTTP patients enrolled in the French Reference Center for Thrombotic Microangiopathies registry between 2000 and 2016 were described according to age (<60 years old or >/=60 years old). Long-term mortality of iTTP older survivors was compared with that of non-iTTP geriatric subjects. Comparing, respectively, older iTTP patients (N = 71) with younger patients (N = 340), time from hospital admission to diagnosis was longer (P < .0001); at diagnosis, delirium (P = .034), behavior impairment (P = .045), renal involvement (P < .0001), and elevated troponin level (P = .025) were more important whereas cytopenias were less profound (platelet count, 22 x 103/mm3 [9-57] vs 13 x 103/mm3 [9-21], respectively [P = .002]; hemoglobin level, 9 g/dL [8-11] vs 8 g/dL [7-10], respectively [P = .0007]). Short- and mid-term mortalities were higher (P < .0001) and increased for every 10 years of age range. Age >/=60 years, cardiac involvement, increased plasma creatinine level, and total plasma exchange volume were independently associated with 1-month mortality. Compared with a non-iTTP geriatric population, older survivors showed an increased long-term mortality (hazard ratio = 3.44; P < .001). In conclusion, older iTTP patients have atypical neurological presentation delaying the diagnosis. Age negatively impacts short-term but also long-term mortality. | |
dc.language.iso | EN | en_US |
dc.subject.en | SEPIA | |
dc.title.en | Immune thrombotic thrombocytopenic purpura in older patients: prognosis and long-term survival | |
dc.title.alternative | Blood | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1182/blood.2019000748 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 31530564 | en_US |
bordeaux.journal | Blood | en_US |
bordeaux.page | 2209-2217 | en_US |
bordeaux.volume | 134 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
bordeaux.issue | 24 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03162621 | |
hal.version | 1 | |
hal.date.transferred | 2021-03-12T10:52:48Z | |
hal.export | true | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Blood&rft.date=2019-12-12&rft.volume=134&rft.issue=24&rft.spage=2209-2217&rft.epage=2209-2217&rft.eissn=1528-0020%20(Electronic)%200006-4971%20(Linking)&rft.issn=1528-0020%20(Electronic)%200006-4971%20(Linking)&rft.au=PREVEL,%20R.&ROUBAUD-BAUDRON,%20C.&GOURLAIN,%20Samuel&JAMME,%20M.&PERES,%20Karine&rft.genre=article |
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