Plasma Copeptin and Risk of Lower-Extremity Amputation in Type 1 and Type 2 Diabetes
| dc.rights.license | open | en_US |
| dc.contributor.author | POTIER, L. | |
| dc.contributor.author | ROUSSEL, R. | |
| dc.contributor.author | MARRE, M. | |
| dc.contributor.author | BJORNSTAD, P. | |
| dc.contributor.author | CHERNEY, D. Z. | |
| dc.contributor.author | EL BOUSTANY, R. | |
| dc.contributor.author | FUMERON, F. | |
| dc.contributor.author | VENTECLEF, N. | |
| dc.contributor.author | GAUTIER, J. F. | |
| dc.contributor.author | HADJADJ, S. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| dc.contributor.author | VELHO, G. | |
| dc.date.accessioned | 2020-07-09T14:10:55Z | |
| dc.date.available | 2020-07-09T14:10:55Z | |
| dc.date.issued | 2019-12 | |
| dc.identifier.issn | 1935-5548 (Electronic) 0149-5992 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10278 | |
| dc.description.abstractEn | OBJECTIVE: Diabetes is the leading cause of nontraumatic lower-extremity amputations (LEAs). Identification of patients with foot ulcers at risk for amputation remains clinically challenging. Plasma copeptin, a surrogate marker of vasopressin, is associated with the risk of cardiovascular and renal complications in diabetes. RESEARCH DESIGN AND METHODS: We assessed the association between baseline plasma copeptin and risk of LEA during follow-up in four cohorts of people with type 1 (GENESIS, n = 503, and GENEDIAB, n = 207) or type 2 diabetes (DIABHYCAR, n = 3,101, and SURDIAGENE, n = 1,452) with a median duration of follow-up between 5 and 10 years. Copeptin concentration was measured in baseline plasma samples by an immunoluminometric assay. RESULTS: In the pooled cohorts with type 1 diabetes (n = 710), the cumulative incidence of LEA during follow-up by increasing tertiles (tertile 1 [TER1], TER2, and TER3) of baseline plasma copeptin was 3.9% (TER1), 3.3% (TER2), and 10.0% (TER3) (P = 0.002). Cox regression analyses confirmed the association of copeptin with LEA: hazard ratio (HR) for 1 SD increment of log[copeptin] was 1.89 (95% CI 1.28-2.82), P = 0.002. In the pooled cohorts of type 2 diabetes (n = 4,553), the cumulative incidence of LEA was 1.1% (TER1), 2.9% (TER2), and 3.6% (TER3) (P < 0.0001). In Cox regression analyses, baseline plasma copeptin was significantly associated with LEA: HR for 1 SD increment of log[copeptin] was 1.42 (1.15-1.74), P = 0.001. Similar results were observed in the cohort with type 2 diabetes for lower-limb revascularization (HR 1.20 [95% CI 1.03-1.39], P = 0.02). CONCLUSIONS: Baseline plasma copeptin is associated with cumulative incidence of LEA in cohorts of people with both type 1 and type 2 diabetes and may help to identify patients at risk for LEA. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | LEHA | |
| dc.title.en | Plasma Copeptin and Risk of Lower-Extremity Amputation in Type 1 and Type 2 Diabetes | |
| dc.title.alternative | Diabetes Care | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.2337/dc19-1062 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31582427 | en_US |
| bordeaux.journal | Diabetes Care | en_US |
| bordeaux.page | 2290-2297 | en_US |
| bordeaux.volume | 42 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 12 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03210822 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-28T08:46:30Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Diabetes%20Care&rft.date=2019-12&rft.volume=42&rft.issue=12&rft.spage=2290-2297&rft.epage=2290-2297&rft.eissn=1935-5548%20(Electronic)%200149-5992%20(Linking)&rft.issn=1935-5548%20(Electronic)%200149-5992%20(Linking)&rft.au=POTIER,%20L.&ROUSSEL,%20R.&MARRE,%20M.&BJORNSTAD,%20P.&CHERNEY,%20D.%20Z.&rft.genre=article |
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