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Agricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPIEL, Clement
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPOUCHIEU, Camille
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCARLES, Camille
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBEZIAT, Beatrix
dc.contributor.authorBOULANGER, Mathilde
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBUREAU, Mathilde
dc.contributor.authorBUSSON, Amandine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRUBER, Anne
dc.contributor.authorLECLUSE, Yannick
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMIGAULT, Lucile
dc.contributor.authorRENIER, Marine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRONDEAU, Virginie
ORCID: 0000-0001-7109-4831
IDREF: 16662988X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSCHWALL, Xavier
dc.contributor.authorTUAL, Severine
dc.contributor.authorLEBAILLY, Pierre
dc.date.accessioned2020-07-09T08:00:11Z
dc.date.available2020-07-09T08:00:11Z
dc.date.issued2019-09
dc.identifier.issn1873-6750 (Electronic) 0160-4120 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10240
dc.description.abstractEnBACKGROUND: Pesticides exposures could be implicated in the excess of Central Nervous System (CNS) tumors observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate derivative pesticides, including herbicides and fungicides (i.e. (thio/dithio)-carbamates), have shown evidence of carcinogenicity in experimental studies in animals. In the French AGRICAN cohort, we assessed the associations between potential exposures to carbamate herbicides and fungicides and the incidence of CNS tumors, overall and by histological subtype. METHODS: AGRICAN enrolled 181,842 participants involved in agriculture. Incident CNS tumors were identified by linkage with cancer registries from enrollment (2005-2007) until 2013. Individual exposures were assessed by combining information on lifetime periods of pesticide use on crops and the French crop-exposure matrix PESTIMAT, for each of the 14 carbamate and thiocarbamate herbicides and the 16 carbamate and dithiocarbamate fungicides registered in France since 1950. Associations were estimated using proportional hazard models with age as the underlying timescale, adjusting for gender, educational level and smoking. RESULTS: During an average follow-up of 6.9years, 381 incident cases of CNS tumors occurred, including 164 gliomas and 134 meningiomas. Analyses showed increased risks of CNS tumors with overall exposure to carbamate fungicides (Hazard Ratio, HR=1.88; 95% CI: 1.27-2.79) and, to a lesser extent, to carbamate herbicides (HR=1.44; 95% CI: 0.94-2.22). Positive associations were observed with specific carbamates, including some fungicides (mancozeb, maneb, metiram) and herbicides (chlorpropham, propham, diallate) already suspected of being carcinogens in humans. CONCLUSIONS: Although some associations need to be corroborate in further studies and should be interpreted cautiously, these findings provide additional carcinogenicity evidence for several carbamate fungicides and herbicides.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.enBiostatistics
dc.subject.enEPICENE
dc.title.enAgricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN
dc.title.alternativeEnviron Inten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envint.2019.05.070en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31344646en_US
bordeaux.journalEnvironment internationalen_US
bordeaux.page104876en_US
bordeaux.volume130en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.teamBIOSTAT_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03169044
hal.version1
hal.date.transferred2021-03-15T08:39:35Z
hal.exporttrue
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