Show simple item record

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

dc.rights.licenseopenen_US
dc.contributor.authorDAMOTTE, Vincent
dc.contributor.authorVAN DER LEE, Sven J.
dc.contributor.authorCHOURAKI, Vincent
dc.contributor.authorGRENIER-BOLEY, Benjamin
dc.contributor.authorSIMINO, Jeannette
dc.contributor.authorADAMS, Hieab
dc.contributor.authorTOSTO, Giuseppe
dc.contributor.authorWHITE, Charles
dc.contributor.authorTERZIKHAN, Natalie
dc.contributor.authorCRUCHAGA, Carlos
dc.contributor.authorKNOL, Maria J.
dc.contributor.authorLI, Shuo
dc.contributor.authorSCHRAEN, Susanna
dc.contributor.authorGROVE, Megan L.
dc.contributor.authorSATIZABAL, Claudia
dc.contributor.authorAMIN, Najaf
dc.contributor.authorBERR, Claudine
dc.contributor.authorYOUNKIN, Steven
dc.contributor.authorALZHEIMER'S DISEASE NEUROIMAGING, Initiative
dc.contributor.authorGOTTESMAN, Rebecca F.
dc.contributor.authorBUEE, Luc
dc.contributor.authorBEISER, Alexa
dc.contributor.authorKNOPMAN, David S.
dc.contributor.authorUITTERLINDEN, Andre
dc.contributor.authorDECARLI, Charles
dc.contributor.authorBRESSLER, Jan
dc.contributor.authorDESTEFANO, Anita
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
dc.contributor.authorYANG, Qiong
dc.contributor.authorBOERWINKLE, Eric
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
IDREF: 69829209
dc.contributor.authorFORNAGE, Myriam
dc.contributor.authorIKRAM, M. Arfan
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorDE JAGER, Phil
dc.contributor.authorREITZ, Christiane
dc.contributor.authorMOSLEY, Thomas H.
dc.contributor.authorLAMBERT, Jean-Charles
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorVAN DUIJN, Cornelia M.
dc.date.accessioned2021-07-05T10:18:03Z
dc.date.available2021-07-05T10:18:03Z
dc.date.issued2021-05-18
dc.identifier.issn1552-5260en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/94976
dc.description.abstractEnINTRODUCTION: There is increasing interest in plasma amyloid beta (Aβ) as an endophenotype of Alzheimer's disease (AD). Identifying the genetic determinants of plasma Aβ levels may elucidate important biological processes that determine plasma Aβ measures. METHODS: We included 12,369 non-demented participants from eight population-based studies. Imputed genetic data and measured plasma Aβ1-40, Aβ1-42 levels and Aβ1-42/Aβ1-40 ratio were used to perform genome-wide association studies, and gene-based and pathway analyses. Significant variants and genes were followed up for their association with brain positron emission tomography Aβ deposition and AD risk. RESULTS: Single-variant analysis identified associations with apolipoprotein E (APOE) for Aβ1-42 and Aβ1-42/Aβ1-40 ratio, and BACE1 for Aβ1-40. Gene-based analysis of Aβ1-40 additionally identified associations for APP, PSEN2, CCK, and ZNF397. There was suggestive evidence for interaction between a BACE1 variant and APOE ε4 on brain Aβ deposition. DISCUSSION: Identification of variants near/in known major Aβ-processing genes strengthens the relevance of plasma-Aβ levels as an endophenotype of AD.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enAlzheimer's disease
dc.subject.enAPOE
dc.subject.enAPP
dc.subject.enBACE1
dc.subject.enEndophenotype
dc.subject.enGenetic epidemiology
dc.subject.enGenome‑wide association study
dc.subject.enPlasma amyloid beta levels
dc.subject.enPlasma biomarkers
dc.subject.enPreclinical biomarkers
dc.subject.enPSEN2
dc.title.enPlasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12333en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34002480en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03278043
hal.version1
hal.date.transferred2021-07-05T10:18:08Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2021-05-18&rft.eissn=1552-5260&rft.issn=1552-5260&rft.au=DAMOTTE,%20Vincent&VAN%20DER%20LEE,%20Sven%20J.&CHOURAKI,%20Vincent&GRENIER-BOLEY,%20Benjamin&SIMINO,%20Jeannette&rft.genre=article


Files in this item

Thumbnail
Name:
BPH_AD_2021_Damotte.pdf
Size:
753.7Kb
Format:
PDF
View/Open
Thumbnail
Name:
license_rdf
Size:
920bytes
Format:
application/rdf+xml
View/Open

This item appears in the following Collection(s)

Show simple item record