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Patterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPILLERON, S.
dc.contributor.authorWEBER, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
dc.contributor.authorCOLPO, M.
dc.contributor.authorGOMEZ-CABRERO, D.
dc.contributor.authorSTUETZ, W.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
dc.contributor.authorFERRUCCI, L.
dc.contributor.authorBANDINELLI, S.
dc.contributor.authorGARCIA-GARCIA, F. J.
dc.contributor.authorGRUNE, T.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
ORCID: 0000-0002-7959-1610
IDREF: 08195848X
dc.date.accessioned2020-07-03T14:07:31Z
dc.date.available2020-07-03T14:07:31Z
dc.date.issued2019-02
dc.identifier.issn1436-6215 (Electronic) 1436-6207 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8576
dc.description.abstractEnPURPOSE: To investigate the cross-sectional and prospective associations between patterns of serum fat-soluble micronutrients and frailty in four European cohorts of older adults 65 years of age and older. METHODS: Participants from the Three-City (Bordeaux, France), AMI (Gironde, France), TSHA (Toledo, Spain) and InCHIANTI (Tuscany, Italy) cohorts with available data on serum alpha-carotene, beta-carotene, lycopene, cryptoxanthin, lutein + zeaxanthin, retinol, alpha-tocopherol, gamma-tocopherol and 25-hydroxyvitamin D3 (25(OH)D) were included. A principal component (PC) analysis was used to derive micronutrient patterns. Frailty was defined using Fried's criteria. Multivariate logistic regression models adjusted for socio-demographic and health-related covariates were performed to assess the association between micronutrient patterns and prevalent frailty in 1324 participants, and the risk of frailty in 915 initially non-frail participants. RESULTS: Three different patterns were identified: the first pattern was characterized by higher serum carotenoids and alpha-tocopherol levels; the second was characterized by high loadings for serum vitamins A and E levels and low loadings for carotenes level; the third one had the highest loading for serum 25(OH)D and cryptoxanthin level and the lowest loading for vitamin A and E. A significant cross-sectional association was only observed between the seconnd PC and prevalent frailty (p = 0.02). Compared to the highest quartile, participants in the lowest quartile-i.e., high carotenes and low vitamins E and A levels-had higher odds of frailty (Odds ratio = 2.2; 95% confidence interval 1.3-3.8). No association with the risk of frailty was observed. CONCLUSIONS: These findings suggest that some specific micronutrient patterns are markers but not predictors of frailty in these European cohorts of older adults.
dc.language.isoENen_US
dc.subject.enLEHA
dc.subject.enSEPIA
dc.title.enPatterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults
dc.title.alternativeEur J Nutren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00394-017-1602-0en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29380043en_US
bordeaux.journalEuropean Journal of Nutritionen_US
bordeaux.page379-389en_US
bordeaux.volume58en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03162489
hal.version1
hal.date.transferred2021-03-08T14:11:53Z
hal.exporttrue
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