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Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)

dc.rights.licenseopenen_US
dc.contributor.authorNAVARRO-MATEU, F.
dc.contributor.authorQUESADA, M. P.
dc.contributor.authorESCAMEZ, T.
dc.contributor.authorALCARAZ, M. J.
dc.contributor.authorSEIQUER DE LA PENA, C.
dc.contributor.authorSALMERON, D.
dc.contributor.authorHUERTA, J. M.
dc.contributor.authorVILAGUT, G.
dc.contributor.authorCHIRLAQUE, M. D.
dc.contributor.authorNAVARRO, C.
hal.structure.identifierLaboratoire de psychologie:Santé et qualité de vie
dc.contributor.authorHUSKY, Mathilde
dc.contributor.authorKESSLER, R. C.
dc.contributor.authorALONSO, J.
dc.contributor.authorMARTINEZ, S.
dc.date.accessioned2020-07-02T12:35:31Z
dc.date.available2020-07-02T12:35:31Z
dc.date.issued2019-09-04
dc.identifier.issn2044-6055en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8468
dc.description.abstractEnOBJECTIVE: To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults. : Design : Retrospective case-control study. SETTING: Cases from the substance unit and controls from a representative sample of the adult general population in the metropolitan area of Murcia (Spain). PARTICIPANTS: Cases were defined as outpatients 18 years old or older currently in the treatment for alcohol, opioids or cocaine use disorders in the clinical unit. Controls were randomly selected among individuals without substance use disorders who participated in the Psychiatric Enquiry to General Population in Southeast Spain-Murcia (PEGASUS-Murcia) project, a cross-sectional study of a representative sample of the adult general population. In all, 142 cases and 531 controls were interviewed and a subsample of 114 cases (80.3%) and 329 controls (62%) provided a biological sample. EXPOSURE: A history of 12 childhood adversities, lifetime mental disorders and sociodemographic variables was assessed with the Composite International Diagnostic Interview (CIDI)version 3.0). Buccal swabs were obtained to genotype the 5-HTTLPR polymorphism with the biallelic and the triallelic classification. MAIN OUTCOME AND MEASURE: Multivariable logistic regression models were performed to estimate adjusted ORs and 95% CI. RESULTS: Childhood adversities were associated with an elevated risk of substance use disorders (OR=5.77, 95% CI 3.46 to 9.61). Homozygotes for the short allele of the 5-HTTLPR polymorphism also showed the elevated risk of substance use disorders for the biallelic and triallelic classification: (1.97 (1.10 to 3.55) and 2.01 (1.11 to 3.64), respectively). No evidence for gene x environment interactions was found. CONCLUSIONS: Childhood adversities and the 5-HTTLPR polymorphism are involved in the aetiology of substance use disorders though findings exploring the existence of a gene-environment interaction were inconclusive.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/us/
dc.title.enChildhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
dc.title.alternativeBMJ Openen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/bmjopen-2019-030328en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31488488en_US
bordeaux.journalBMJ Openen_US
bordeaux.pagee030328en_US
bordeaux.volume9en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ%20Open&rft.date=2019-09-04&rft.volume=9&rft.issue=9&rft.spage=e030328&rft.epage=e030328&rft.eissn=2044-6055&rft.issn=2044-6055&rft.au=NAVARRO-MATEU,%20F.&QUESADA,%20M.%20P.&ESCAMEZ,%20T.&ALCARAZ,%20M.%20J.&SEIQUER%20DE%20LA%20PENA,%20C.&rft.genre=article


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