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Indoxyl sulfate associates with cardiovascular phenotype in children with chronic kidney disease

dc.rights.licenseopenen_US
dc.contributor.authorHOLLE, J.
dc.contributor.authorQUERFELD, U.
dc.contributor.authorKIRCHNER, M.
dc.contributor.authorANNINOS, A.
dc.contributor.authorOKUN, J.
dc.contributor.authorTHURN-VALSASSINA, D.
dc.contributor.authorBAYAZIT, A.
dc.contributor.authorNIEMIRSKA, A.
dc.contributor.authorCANPOLAT, N.
dc.contributor.authorBULUT, I. K.
dc.contributor.authorDUZOVA, A.
dc.contributor.authorANARAT, A.
dc.contributor.authorSHROFF, R.
dc.contributor.authorBILGINER, Y.
dc.contributor.authorCALISKAN, S.
dc.contributor.authorCANDAN, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorOZCAKAR, Z. B.
dc.contributor.authorSOYLEMEZOGLU, O.
dc.contributor.authorTSCHUMI, S.
dc.contributor.authorHABBIG, S.
dc.contributor.authorYILMAZ, E.
dc.contributor.authorBALAT, A.
dc.contributor.authorZUROWSKA, A.
dc.contributor.authorCAKAR, N.
dc.contributor.authorKRANZ, B.
dc.contributor.authorERTAN, P.
dc.contributor.authorMELK, A.
dc.contributor.authorAZUKAITIS, K.
dc.contributor.authorSCHAEFER, F.
dc.date.accessioned2020-06-23T08:24:19Z
dc.date.available2020-06-23T08:24:19Z
dc.date.issued2019-12
dc.identifier.issn0931-041xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8093
dc.description.abstractEnBACKGROUND: Cardiovascular disease is the leading cause of death in children with chronic kidney disease (CKD). Serum levels of gut-derived uremic toxins increase with deterioration of kidney function and are associated with cardiac comorbidities in adult CKD patients. METHODS: Indoxyl sulfate (IS) and p-cresyl sulfate (pCS) were measured by high-performance liquid chromatography in serum of children participating in the Cardiovascular Comorbidity in Children with CKD (4C) Study. Results were correlated with measurements of the carotid intima-media thickness (cIMT), central pulse wave velocity (PWV), and left ventricular mass index (LVMI) in children aged 6-17 years with initial eGFR of 10-60 ml/min per 1.73 m(2). RESULTS: The median serum levels of total IS and of pCS, measured in 609 patients, were 5.3 mumol/l (8.7) and 17.0 mumol/l (21.6), respectively. In a multivariable regression model, IS and pCS showed significant positive associations with urea and negative associations with eGFR and uric acid. Furthermore, positive associations of pCS with age, serum albumin, and non-Mediterranean residency and a negative association with glomerular disease were observed. By multivariable regression analysis, only IS was significantly associated with a higher cIMT SDS at baseline and progression of PWV SDS within 12 months, independent of other risk factors. CONCLUSIONS: Serum levels of gut-derived uremic toxins IS and pCS correlated inversely with eGFR in children. Only IS was significantly associated with surrogate markers of cardiovascular disease in this large pediatric CKD cohort.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enIndoxyl sulfate associates with cardiovascular phenotype in children with chronic kidney disease
dc.title.alternativePediatr Nephrolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00467-019-04331-6en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31428929en_US
bordeaux.journalPediatric Nephrologyen_US
bordeaux.page2571-2582en_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209926
hal.version1
hal.date.transferred2021-04-27T13:33:28Z
hal.exporttrue
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