Afficher la notice abrégée

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

dc.rights.licenseopenen_US
dc.contributor.authorHARRIS, William S.
dc.contributor.authorTINTLE, Nathan L.
dc.contributor.authorIMAMURA, Fumiaki
dc.contributor.authorQIAN, Frank
dc.contributor.authorKORAT, Andres V. Ardisson
dc.contributor.authorMARKLUND, Matti
dc.contributor.authorDJOUSSE, Luc
dc.contributor.authorBASSETT, Julie K.
dc.contributor.authorCARMICHAEL, Pierre-Hugues
dc.contributor.authorCHEN, Yun-Yu
dc.contributor.authorHIRAKAWA, Yoichiro
dc.contributor.authorKÜPERS, Leanne K.
dc.contributor.authorLAGUZZI, Federica
dc.contributor.authorLANKINEN, Maria
dc.contributor.authorMURPHY, Rachel A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorSENN, Mackenzie
dc.contributor.authorSHI, Peilin
dc.contributor.authorVIRTANEN, Jyrki K.
dc.contributor.authorBROUWER, Ingeborg A.
dc.contributor.authorCHIEN, Kuo-Liong
dc.contributor.authorEIRIKSDOTTIR, Gudny
dc.contributor.authorFOROUHI, Nita G.
dc.contributor.authorGELEIJNSE, Johanna M.
dc.contributor.authorGILES, Graham G.
dc.contributor.authorGUDNASON, Vilmundur
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorHODGE, Allison
dc.contributor.authorJACKSON, Rebecca
dc.contributor.authorKHAW, Kay-Tee
dc.contributor.authorLAAKSO, Markku
dc.contributor.authorLAI, Heidi
dc.contributor.authorLAURIN, Danielle
dc.contributor.authorLEANDER, Karin
dc.contributor.authorLINDSAY, Joan
dc.contributor.authorMICHA, Renata
dc.contributor.authorMURSU, Jaako
dc.contributor.authorNINOMIYA, Toshiharu
dc.contributor.authorPOST, Wendy
dc.contributor.authorPSATY, Bruce M.
dc.contributor.authorRISERUS, Ulf
dc.contributor.authorROBINSON, Jennifer G.
dc.contributor.authorSHADYAB, Aladdin H.
dc.contributor.authorSNETSELAAR, Linda
dc.contributor.authorSALA-VILA, Aleix
dc.contributor.authorSUN, Yangbo
dc.contributor.authorSTEFFEN, Lyn M.
dc.contributor.authorTSAI, Michael Y.
dc.contributor.authorWAREHAM, Nicolas J.
dc.contributor.authorWOOD, Alexis C.
dc.contributor.authorWU, Jason H. Y.
dc.contributor.authorHU, Frank
dc.contributor.authorSUN, Qi
dc.contributor.authorSISCOVICK, David S.
dc.contributor.authorLEMAITRE, Rozenn N.
dc.contributor.authorMOZAFFARIAN, Dariush
dc.date.accessioned2021-06-29T08:10:50Z
dc.date.available2021-06-29T08:10:50Z
dc.date.issued2021-04-22
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79311
dc.description.abstractEnThe health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enPredictive markers
dc.subject.enRisk factors
dc.title.enBlood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-021-22370-2en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33888689en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page2329en_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.teamVINTAGE
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03273286
hal.version1
hal.date.transferred2021-06-29T08:10:57Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Nature%20Communications&amp;rft.date=2021-04-22&amp;rft.volume=12&amp;rft.issue=1&amp;rft.spage=2329&amp;rft.epage=2329&amp;rft.eissn=2041-1723&amp;rft.issn=2041-1723&amp;rft.au=HARRIS,%20William%20S.&amp;TINTLE,%20Nathan%20L.&amp;IMAMURA,%20Fumiaki&amp;QIAN,%20Frank&amp;KORAT,%20Andres%20V.%20Ardisson&amp;rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_NC_2021_Harris.pdf
Taille:
1.225Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée