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Normalization of hippocampal retinoic acid level corrects age-related memory deficits in rats

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUMETZ, Fabien
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBURE, Corinne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorALFOS, Serge
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBONNEU, Marc
hal.structure.identifierBiothérapies des maladies génétiques et cancers
dc.contributor.authorRICHARD, Emmanuel
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTOUYAROT, Katia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARIE, Anais
dc.contributor.authorSCHMITTER, Jean-Marie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPALLET, Veronique
ORCID: 0000-0002-9078-3269
IDREF: 066841763
dc.date.accessioned2020-06-15T13:35:55Z
dc.date.available2020-06-15T13:35:55Z
dc.date.issued2019
dc.identifier.otherhttps://doi.org/10.1016/j.neurobiolaging.2019.09.016en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7926
dc.description.abstractEnDietary micronutrients constitute a major environmental factor influencing aging processes. Vitamin A (vit. A) is the precursor of retinoic acid, a bioactive molecule that controls the expression of several genes involved in brain function. Evidence suggests a reduction of vit. A bioavailability with aging, but its impact on neuronal network is poorly understood. We investigated the mechanisms linking memory impairments with specific alterations of retinoic acid metabolism in the hippocampus. We compared young (10weeks) and aged (16months) rats, supplemented or not with dietary vit. A (20 IU retinol/g) for 4weeks. Our study reveals that aging induced dysregulation of gene expression involved in vit. A and retinoic acid metabolism in the liver. Furthermore, vit. A supplementation restored the integrity of the hippocampal neuronal morphology altered by aging. Importantly, we found a high correlation between hippocampal levels of retinoic acid and memory performance. The present work establishes the link between collapse of retinoid metabolism and age-related cognitive decline, highlighting the role of vit. A in maintaining memory through aging.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-04-01/10-INBS-0004en_US
dc.language.isoENen_US
dc.subject.enAging
dc.subject.enRetinol
dc.subject.enRetinoic acid
dc.subject.enMemory
dc.subject.enNeuronal morphology
dc.subject.enHippocampus
dc.title.enNormalization of hippocampal retinoic acid level corrects age-related memory deficits in rats
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neurobiolaging.2019.09.016
dc.subject.halChimie/Matériauxen_US
bordeaux.journalNeurobiology of Agingen_US
bordeaux.page1-10en_US
bordeaux.volume85en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAE
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03182239
hal.version1
hal.date.transferred2021-03-26T10:17:21Z
hal.exporttrue
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