DUMETZ, Fabien; BURE, Corinne; ALFOS, Serge; BONNEU, Marc; RICHARD, Emmanuel; TOUYAROT, Katia; MARIE, Anais; SCHMITTER, Jean-Marie; BOSCH BOUJU, Clementine; PALLET, Veronique

doi:10.1016/j.neurobiolaging.2019.09.016

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DUMETZ, Fabien
Nutrition et Neurobiologie intégrée [NutriNeuro]

BURE, Corinne
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

ALFOS, Serge
Nutrition et Neurobiologie intégrée [NutriNeuro]

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Neurobiology of Aging. 2019, vol. 85, p. 1-10

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Dietary micronutrients constitute a major environmental factor influencing aging processes. Vitamin A (vit. A) is the precursor of retinoic acid, a bioactive molecule that controls the expression of several genes involved in brain function. Evidence suggests a reduction of vit. A bioavailability with aging, but its impact on neuronal network is poorly understood. We investigated the mechanisms linking memory impairments with specific alterations of retinoic acid metabolism in the hippocampus. We compared young (10weeks) and aged (16months) rats, supplemented or not with dietary vit. A (20 IU retinol/g) for 4weeks. Our study reveals that aging induced dysregulation of gene expression involved in vit. A and retinoic acid metabolism in the liver. Furthermore, vit. A supplementation restored the integrity of the hippocampal neuronal morphology altered by aging. Importantly, we found a high correlation between hippocampal levels of retinoic acid and memory performance. The present work establishes the link between collapse of retinoid metabolism and age-related cognitive decline, highlighting the role of vit. A in maintaining memory through aging.< Leer menos

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Aging

Retinol

Retinoic acid

Memory

Neuronal morphology

Hippocampus

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Développment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-04-01/10-INBS-0004

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Normalization of hippocampal retinoic acid level corrects age-related memory deficits in rats

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Normalization of hippocampal retinoic acid level corrects age-related memory deficits in rats

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URI

DOI

Link to research data

Proyecto ANR

Centros de investigación