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dc.contributor.authorRAMI, Lila
hal.structure.identifierIngénierie des Matériaux Polymères [IMP]
dc.contributor.authorMALAISE, Sébastien
dc.contributor.authorDELMOND, Samantha
hal.structure.identifierBiomatériaux et réparation tissulaire
dc.contributor.authorFRICAIN, Jean-Christophe
ORCID: 0000-0001-7855-6437
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSIADOUS, Robin
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSCHLAUBITZ, Silke
hal.structure.identifierCentre de recherches Paul Pascal [CRPP]
dc.contributor.authorLAURICHESSE, Eric
dc.contributor.authorAMEDEE, Joelle
hal.structure.identifierIngénierie des Matériaux Polymères [IMP]
dc.contributor.authorMONTEMBAULT, Alexandra
hal.structure.identifierIngénierie des Matériaux Polymères [IMP]
dc.contributor.authorDAVID, Laurent
hal.structure.identifierBiomateriaux et Reparation Tissulaire
dc.contributor.authorBORDENAVE, Laurence
dc.date.accessioned2021-06-10T07:05:56Z
dc.date.available2021-06-10T07:05:56Z
dc.date.issued2014-10
dc.identifier.issn1549-3296
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79054
dc.description.abstractEnPolysaccharide-based hydrogels are remarkable materials for the development of tissue engineering strategies as they meet several critical requirements for such applications and they may partly mimic the extracellular matrix. Chitosan is widely envisioned as hydrogel in biomedical fields for its bioresorbability, biocompatibility, and fungistatic and bacteriostatic properties. In this study, we report that the modulation of the polymer concentration, the degree of acetylation, the gelation processes [or neutralization routes (NR)] in the preparation of different chitosan-based hydrogels lead to substantially and significantly different biological responses. We show that it is possible to tune the physicochemical characteristics, mechanical properties, and biological responses of such matrices. Physical hydrogels prepared from highly acetylated chitosan were softer, degraded quickly in vivo, and were not suitable for in vitro culture of human mesenchymal stem and progenitor derived endothelial cells. In contrast, for a same chitosan concentration and obtained by the same processing route, a low degree of acetylation chitosan hydrogel provided a more elastic material, better cell adhesion on its surface and tissue regeneration, and restored tissue neo-vascularization as well. This work offers promising and innovative perspectives for the design of hydrogel materials with tunable properties for tissue engineering and regenerative medicine.
dc.language.isoen
dc.publisherWiley
dc.subject.enphysical hydrogels
dc.subject.enchitosan
dc.subject.entunable properties
dc.subject.enhuman cell culture
dc.subject.entissue engineering
dc.title.enPhysicochemical modulation of chitosan-based hydrogels induces different biological responses: Interest for tissue engineering
dc.typeArticle de revue
dc.identifier.doi10.1002/jbm.a.35035
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
bordeaux.journalJournal of Biomedical Materials Research Part A
bordeaux.page3666-3676
bordeaux.volume102
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-01089661
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01089661v1
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