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Postoperative Morbidity After Iterative Ileocolonic Resection for Crohn’s Disease: Should we be Worried? A Prospective Multicentric Cohort Study of the GETAID Chirurgie

hal.structure.identifierSorbonne Université [SU]
dc.contributor.authorABDALLA, Solafah
hal.structure.identifierService de Chirurgie générale et digestive [CHU Le Kremlin-Bicêtre]
dc.contributor.authorBROUQUET, Antoine
hal.structure.identifierService de Gastroentérologie [Hôpital Beaujon]
dc.contributor.authorMAGGIORI, Léon
hal.structure.identifierService de Chirurgie Générale et Digestive[Lille]
dc.contributor.authorZERBIB, Philippe
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDENOST, Quentin
hal.structure.identifierService de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy]
dc.contributor.authorGERMAIN, Adeline
hal.structure.identifierCiblage thérapeutique en Oncologie [EA3738]
dc.contributor.authorCOTTE, Eddy
hal.structure.identifierLaboratoire de Biomécanique Appliquée [LBA UMR T24]
dc.contributor.authorBEYER-BERJOT, Laura
hal.structure.identifierHopital Saint-Louis [AP-HP] [AP-HP]
dc.contributor.authorMUNOZ-BONGRAND, Nicolas
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
dc.contributor.authorDESFOURNEAUX, Véronique
hal.structure.identifierCentre Hospitalier Universitaire de Nice [CHU Nice]
dc.contributor.authorRAHILI, Amine
hal.structure.identifierChirurgie Générale et Digestive [Rangueil]
dc.contributor.authorDUFFAS, Jean-Pierre
hal.structure.identifierHôpital Lariboisière-Fernand-Widal [APHP]
dc.contributor.authorPAUTRAT, Karine
hal.structure.identifierHôpital Lariboisière
dc.contributor.authorDENET, Christine
hal.structure.identifierService de Chirurgie Digestive [CHU Rouen]
hal.structure.identifierNutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau [ADEN]
hal.structure.identifierInstitute for Research and Innovation in Biomedicine [IRIB]
hal.structure.identifierUNIROUEN - UFR Santé [UNIROUEN UFR Santé]
dc.contributor.authorBRIDOUX, Valérie
hal.structure.identifierService de Chirurgie Digestive et Endocrinienne [CHU Nantes] [Hôtel Dieu]
dc.contributor.authorMEURETTE, Guillaume
hal.structure.identifierService de Chirurgie Digestive, [CHRU Grenoble], La Tronche
dc.contributor.authorFAUCHERON, Jean-Luc
hal.structure.identifierService de Chirurgie digestive [GH Paris Saint-Joseph]
dc.contributor.authorLORIAU, Jérôme
hal.structure.identifierDépartement de chirurgie digestive, [CHU Montpellier]
dc.contributor.authorGUILLON, Françoise
hal.structure.identifierHôpital Lariboisière
dc.contributor.authorVICAUT, Eric
hal.structure.identifierService de Chirurgie générale et digestive [CHU Le Kremlin-Bicêtre]
dc.contributor.authorBENOIST, Stéphane
hal.structure.identifierHôpital Beaujon
dc.contributor.authorPANIS, Yves
hal.structure.identifierSorbonne Université [SU]
dc.contributor.authorLEFÈVRE, Jérémie
dc.date.accessioned2021-06-10T07:04:43Z
dc.date.available2021-06-10T07:04:43Z
dc.date.issued2019
dc.identifier.issn1873-9946
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78993
dc.description.abstractEnBACKGROUND AND AIMS: To compare perioperative characteristics and outcomes between primary ileocolonic resection [PICR] and iterative ileocolic resection [IICR] for Crohn's disease [CD].METHODS: From 2013 to 2015, 567 patients undergoing ileocolonic resection were prospectively included in 19 centres of the GETAID chirurgie group. Perioperative characteristics and postoperative results of both groups [431 PICR, 136 IICR] were compared. Uni- and multivariate analyses of the risk factors of overall 30-day postoperative morbidity was carried out in the IICR group.RESULTS: IICR patients were less likely to be malnourished [27.2% vs 39.9%, p = 0.007], and had more stricturing forms [69.1% vs 54.3%, p = 0.002] and less perforating disease [19.9% vs 39.2%, p < 0.001]. Laparoscopy was less commonly used in IICR [45.6% vs 84.5%, p < 0.01] and was associated with increased conversion rates [27.4% vs 14.6%, p = 0.012]. Overall postoperative morbidity was 36.8% in the IICR group and 26.7% in the PICR group [p = 0.024]. There was no significant difference between IICR and PICR regarding septic intra-abdominal complications, anastomotic leakage [8.8% vs 8.4%] or temporary stoma requirement. IICR patients were more likely to present with non-infectious complications and ileus [11.8% vs 3.7%, p < 0.001]. Uni- and multivariate analyses did not identify specific risk factors of overall postoperative morbidity in the IICR group.CONCLUSIONS: Surgery for recurrent CD is associated with a slight increase of non-infectious morbidity [postoperative ileus] that mainly reflects the technical difficulties of these procedures. However, IICR remains a safe therapeutic option in patients with recurrent CD because severe morbidity including anastomotic complications is similar to patients undergoing primary resection.
dc.language.isoen
dc.publisherElsevier - Oxford University Press
dc.subject.enmorbidity
dc.subject.enCrohn’s disease
dc.subject.enrecurrent disease
dc.subject.enileo-colic resection
dc.title.enPostoperative Morbidity After Iterative Ileocolonic Resection for Crohn’s Disease: Should we be Worried? A Prospective Multicentric Cohort Study of the GETAID Chirurgie
dc.typeArticle de revue
dc.identifier.doi10.1093/ecco-jcc/jjz091
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Hépatologie et Gastroentérologie
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Chirurgie
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.journalJournal of Crohn's and Colitis
bordeaux.page1510–1517
bordeaux.volume13
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue12
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-02362759
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02362759v1
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