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A Unique Triculture Model to Study Osteoblasts, Osteoclasts, and Endothelial Cells

hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierPôle d’Odontologie et de Santé Buccale [CHU Bordeaux]
dc.contributor.authorGREMARE, Agathe
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierPôle d’Odontologie et de Santé Buccale [CHU Bordeaux]
dc.contributor.authorAUSSEL, Audrey
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBAREILLE, Reine
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorPAIVA DOS SANTOS, Bruno
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAMÉDÉE, Joëlle
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierPôle d’Odontologie et de Santé Buccale [CHU Bordeaux]
dc.contributor.authorTHÉBAUD, Noelie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorLE NIHOUANNEN, Damien
dc.date.accessioned2021-06-10T07:04:20Z
dc.date.available2021-06-10T07:04:20Z
dc.date.issued2019-07
dc.identifier.issn1937-3384
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78967
dc.description.abstractEnIn this article, we first developed a new medium to culture together primary human osteoblastic, osteoclastic, and endothelial cells (ECs) chosen to represent the three major bone cell tissues. Indeed, no study has been conducted on primary human cells and on the phenotype/activity retention of these three primary human cell types. Thus, we established an original triculture model with osteoblastic, osteoclastic, and ECs, where not only both cell phenotype and cell activity were maintained but also cell culture homeostasis. These promising results will permit further investigations to create in vitro conditions to mimic the bone microenvironment and analyze cell interactions in ex vivo studies.
dc.language.isoen
dc.publisherMary Ann Liebert
dc.subject.encell phenotype
dc.subject.enculture medium
dc.subject.enhuman primary cells
dc.subject.entriculture model.
dc.title.enA Unique Triculture Model to Study Osteoblasts, Osteoclasts, and Endothelial Cells
dc.typeArticle de revue
dc.identifier.doi10.1089/ten.TEC.2018.0301
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Biomatériaux
bordeaux.journalTissue Engineering Part C: Methods
bordeaux.page421-432
bordeaux.volume25
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue7
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02863405
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02863405v1
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