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MRI assessment of multiple dipolar relaxation time (T1D) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer (ihMT) model

dc.rights.licenseopenen_US
dc.contributor.authorCARVALHO, Victor N. D.
dc.contributor.authorHERTANU, Andreea
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGRELARD, Axelle
dc.contributor.authorMCHINDA, Samira
dc.contributor.authorSOUSTELLE, Lucas
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLOQUET, Antoine
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDUFOURC, Erick J.
dc.contributor.authorVARMA, Gopal
dc.contributor.authorALSOP, David C.
dc.contributor.authorTHUREAU, Pierre
dc.contributor.authorGIRARD, Olivier M.
dc.contributor.authorDUHAMEL, Guillaume
dc.date.accessioned2020-06-11T15:59:28Z
dc.date.available2020-06-11T15:59:28Z
dc.date.issued2019
dc.identifier.issn1090-7807en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7895
dc.description.abstractEnT1D, the relaxation time of dipolar order, is sensitive to slow motional processes. Thus T1D is a probe for membrane dynamics and organization that could be used to characterize myelin, the lipid-rich membrane of axonal fibers. A mono-component T1D model associated with a modified ihMT sequence was previously proposed for in vivo evaluation of T1D with MRI. However, experiments have suggested that myelinated tissues exhibit multiple T1D components probably due to a heterogeneous molecular mobility. A bi-component T1D model is proposed and implemented. ihMT images of ex-vivo, fixed rat spinal cord were acquired with multiple frequency alternation rate. Fits to data yielded two T1Ds of about 500mus and 10ms. The proposed model seems to further explore the complexity of myelin organization compared to the previously reported mono-component T1D model.
dc.language.isoENen_US
dc.subject.enDipolar relaxation time
dc.subject.enInhomogeneous magnetization transfer
dc.subject.enihMT
dc.subject.enMRI contrast
dc.subject.enJeener-Broekaert
dc.subject.enMyelin
dc.subject.enMyelin Imaging
dc.title.enMRI assessment of multiple dipolar relaxation time (T1D) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer (ihMT) model
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jmr.2019.106668
dc.subject.halChimie/Matériauxen_US
bordeaux.journalJournal of Magnetic Resonanceen_US
bordeaux.page106668-106668en_US
bordeaux.volume311en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03182143
hal.version1
hal.date.transferred2021-03-26T09:51:17Z
hal.exporttrue
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