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A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective in situ angiogenesis

hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
dc.contributor.authorSACHOT, Nadège
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierUniversitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona [UAB]
dc.contributor.authorCASTANO, Oscar
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorOLIVEIRA, Hugo
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
dc.contributor.authorMARTÍ-MUÑOZ, Joan
dc.contributor.authorROGUSKA, A.
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAMÉDÉE, Joëlle
hal.structure.identifierWarsaw University of Technology [Warsaw]
dc.contributor.authorLEWANDOWSKA, M.
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
dc.contributor.authorPLANELL, J.
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierTechnical University of Catalonia [Barcelona] [UPC]
dc.contributor.authorENGEL, E.
dc.date.accessioned2021-06-10T07:03:55Z
dc.date.available2021-06-10T07:03:55Z
dc.date.issued2016-11
dc.identifier.issn2050-750X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78942
dc.description.abstractEnAlthough the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of polylactic acid (PLA) and a microparticle glass of 5TiO2-44.5CaO-44.5P2O5-6Na2O (G5) molar ratio have already demonstrated in situ osteo- and angiogenesis-triggering abilities. As many of the hybrid materials currently developed usually promote osteogenesis but still lack the ability to induce vascularization, a G5/PLA combination is a cost-effective option for obtaining new instructive scaffolds. In this study, nanostructured PLA-ORMOGLASS (organically modified glass) fibers were produced by electrospinning, in order to fabricate extra-cellular matrix (ECM)-like substrates that simultaneously promote bone formation and vascularization. Physical-chemical and surface characterization and tensile tests demonstrated that the obtained scaffolds exhibited homogeneous morphology, higher hydrophilicity and enhanced mechanical properties than pure PLA. In vitro assays with rat mesenchymal stem cells (rMSCs) and rat endothelial progenitor cells (rEPCs) also showed that rMSCs attached and proliferated on the materials influenced by the calcium content in the environment. In vivo assays showed that hybrid composite PLA-ORMOGLASS fibers were able to promote the formation of blood vessels. Thus, these novel fibers are a valid option for the design of functional materials for tissue engineering applications.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.title.enA novel hybrid nanofibrous strategy to target progenitor cells for cost-effective in situ angiogenesis
dc.typeArticle de revue
dc.identifier.doi10.1039/c6tb02162j
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalJournal of materials chemistry‎ B
bordeaux.page6967-6978
bordeaux.volume4
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue43
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02870939
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02870939v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20materials%20chemistry%E2%80%8E%20B&rft.date=2016-11&rft.volume=4&rft.issue=43&rft.spage=6967-6978&rft.epage=6967-6978&rft.eissn=2050-750X&rft.issn=2050-750X&rft.au=SACHOT,%20Nad%C3%A8ge&CASTANO,%20Oscar&OLIVEIRA,%20Hugo&MART%C3%8D-MU%C3%91OZ,%20Joan&ROGUSKA,%20A.&rft.genre=article


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