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The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment

hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorOLIVEIRA, Hugo
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCATROS, Sylvain
ORCID: 0000-0002-3419-3467
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBOIZIAU, Claudine
ORCID: 0000-0002-0475-2571
IDREF: 85228370
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSIADOUS, Robin
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
dc.contributor.authorMARTI-MUNOZ, Joan
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBAREILLE, Reine
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorREY, Sylvie
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierUniversitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona [UAB]
dc.contributor.authorCASTANO, Oscar
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierUniversitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona [UAB]
dc.contributor.authorPLANELL, Josep
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAMEDEE, Joelle
ORCID: 0000-0002-4888-0129
IDREF: 87485605
hal.structure.identifierInstitute for Bioengineering of Catalonia [Barcelona] [IBEC]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierUniversitat Politècnica de Catalunya = Université polytechnique de Catalogne [Barcelona] [UPC]
dc.contributor.authorENGEL, Elisabeth
dc.date.accessioned2021-06-10T07:03:53Z
dc.date.available2021-06-10T07:03:53Z
dc.date.issued2016-01
dc.identifier.issn1742-7061
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78940
dc.description.abstractEnIn current bone tissue engineering strategies the achievement of sufficient angiogenesis during tissue regeneration is still a major limitation in order to attain full functionality. Several strategies have been described to tackle this problem, mainly by the use of angiogenic factors or endothelial progenitor cells. However, when facing a clinical scenario these approaches are inherently complex and present a high cost. As such, more cost effective alternatives are awaited. Here, we demonstrate the potential of electrospun poly(lactic acid) (PLA) fiber-based membranes, containing calcium phosphate ormoglass (CaP) particles, to elicit angiogenesis in vivo, in a subcutaneous model in mice. We show that the current approach elicited the local expression of angiogenic factors, associated to a chemotactic effect on macrophages, and sustained angiogenesis into the biomaterial. As both PLA and CaP are currently accepted for clinical application these off-the-shelf novel membranes have great potential for guided bone regeneration applications.Statement of significance: In current bone tissue engineering approaches the achievement of sufficient angiogenesis, during tissue regeneration, is a major limitation in order to attain full tissue functionality. Recently, our group has found that calcium ions released by the degradation of calcium phosphate ormoglasses (CaP) are effective angiogenic promoters. Based on this, in this work we successfully produced hybrid fibrous mats with different contents of CaP nanoparticles and thus with different calcium ion release rates, using an ormoglass - poly(lactic acid) blend approach. We show that these matrices, upon implantation in a subcutaneous site, could elicit the local expression of angiogenic factors, associated to a chemotactic effect on macrophages, and sustained angiogenesis into the biomaterial, in a CaP dose dependent manner. This off-the-shelf cost effective approach presents great potential to translate to the clinics.
dc.language.isoen
dc.publisherElsevier
dc.subject.enAngiogenesis
dc.subject.enBone regeneration
dc.subject.enCalcium phosphate ormoglass
dc.title.enThe proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment
dc.typeArticle de revue
dc.identifier.doi10.1016/j.actbio.2015.10.003
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalActa Biomaterialia
bordeaux.page435-445
bordeaux.volume29
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02870944
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02870944v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta%20Biomaterialia&rft.date=2016-01&rft.volume=29&rft.spage=435-445&rft.epage=435-445&rft.eissn=1742-7061&rft.issn=1742-7061&rft.au=OLIVEIRA,%20Hugo&CATROS,%20Sylvain&BOIZIAU,%20Claudine&SIADOUS,%20Robin&MARTI-MUNOZ,%20Joan&rft.genre=article


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