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A disulfide based low molecular weight gel for the selective sustained release of biomolecules

hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorBANSODE, Nitin
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSINDHU, Kotagudda Ranganath
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorMOREL, Chloe
IDREF: 257498346
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorRÉMY, Murielle
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorVERGET, Julien
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBOIZIAU, Claudine
ORCID: 0000-0002-0475-2571
IDREF: 85228370
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorBARTHELEMY, Philippe
dc.date.accessioned2021-06-10T07:03:48Z
dc.date.available2021-06-10T07:03:48Z
dc.date.issued2020-07
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78935
dc.description.abstractEnConstructing biocompatible soft materials via supramolecular approaches remains an important challenge for in vivo applications. Substantial efforts have been made to develop biocompatible non-polymeric materials allowing sustained release of biomolecules and/or drugs in vivo. Herein, we introduce disulfide based low molecular weight gels (LMWGs) allowing the in vitro selective sustained release of proteins containing thiol residues. The novel glycosylated nucleoside based bola-amphiphile (GNBA), which features a disulfide bond inserted in the hydrophobic segment, self-assembles to stabilize the resulting hydrogel. Rheological studies show the dominant elastic character and thixotropic properties of the disulfide LMWG demonstrating its injectability. In vitro and in vivo biodegradation investigations reveal that the disulfide LMWG is stable for several weeks. Importantly, disulfide bonds can be cleaved through the thiol-disulfide exchange reactions with small redox molecules such as dithiothreitol (DTT). The disulfide LMWG loaded with a thiol-containing protein (bovine serum albumin) features sustained release in vitro, whereas a dextran of the same molecular weight, lacking a thiol biomolecule, shows quick release. The disulfide GNBA is the first example of a LMWG allowing selective long term sustained release in vitro via a disulfide reshuffling mechanism.
dc.language.isoen
dc.publisherRoyal Society of Chemistry (RSC)
dc.title.enA disulfide based low molecular weight gel for the selective sustained release of biomolecules
dc.typeArticle de revue
dc.identifier.doi10.1039/d0bm00508h
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalBiomaterials Science
bordeaux.page3186-3192
bordeaux.volume8
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue11
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierinserm-02870963
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-02870963v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomaterials%20Science&rft.date=2020-07&rft.volume=8&rft.issue=11&rft.spage=3186-3192&rft.epage=3186-3192&rft.au=BANSODE,%20Nitin&SINDHU,%20Kotagudda%20Ranganath&MOREL,%20Chloe&R%C3%89MY,%20Murielle&VERGET,%20Julien&rft.genre=article


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