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Adverse Drug Reactions in Patients with CKD

hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorLAVILLE, Solène
hal.structure.identifierCHU Amiens-Picardie
dc.contributor.authorGRAS-CHAMPEL, Valérie
hal.structure.identifierCHU Amiens-Picardie
dc.contributor.authorMORAGNY, Julien
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorMETZGER, Marie
hal.structure.identifierAgence de la biomédecine [Saint-Denis la Plaine]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorJACQUELINET, Christian
hal.structure.identifierCHU Bordeaux
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorFOUQUE, Denis
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorLAVILLE, Maurice
hal.structure.identifierMaladies chroniques, santé perçue, et processus d'adaptation [APEMAC]
hal.structure.identifierService de Néphrologie [CHRU Nancy]
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierArbor Research Collaborative for Health
dc.contributor.authorROBINSON, Bruce
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSTENGEL, Bénédicte
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierService Néphrologie/Dialyse [AP-HP Ambroise-Paré]
dc.contributor.authorMASSY, Ziad
hal.structure.identifierMécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 [MP3CV]
hal.structure.identifierCHU Amiens-Picardie
dc.contributor.authorLIABEUF, Sophie
dc.date.accessioned2021-06-10T07:03:32Z
dc.date.available2021-06-10T07:03:32Z
dc.date.issued2020
dc.identifier.issn1555-9041
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78922
dc.description.abstractEnBackground and objectives Little is known about the burden of adverse drug reactions in CKD. We estimated the incidence of overall and serious adverse drug reactions and assessed the probability of causation, preventability, and factors associated with adverse drug reactions in patients seen by nephrologists.Design, setting, participants, & measurements The Chronic Kidney Disease-Renal Epidemiology and Information Network cohort included 3033 outpatients (65% men) with CKD and eGFR<60 ml/min per 1.73 m2, with follow-up for 2 years. Adverse drug reactions were identified from hospitalization reports, medical records, and participant interviews and finally assessed for causality, preventability, and immediate therapeutic management by experts in pharmacology.Results Median (interquartile range) age was 69 (60–76) years old; 55% had eGFR≥30 ml/min per 1.73 m2, and 45% had eGFR<30 ml/min per 1.73 m2. Participants were prescribed a median (range) of eight (five to ten) drugs. Over 2 years, 536 patients had 751 adverse drug reactions, 150 (in 125 participants) classified as serious, for rates of 14.4 (95% confidence interval, 12.6 to 16.5) and 2.7 (95% confidence interval, 1.7 to 4.3) per 100 person-years, respectively. Among the serious adverse drug reactions, 32% were considered preventable or potentially preventable; 16 caused death, directly or indirectly. Renin-angiotensin system inhibitors (15%), antithrombotic agents (14%), and diuretics (10%) were the drugs to which the most adverse drug reactions were imputed, but antithrombotic agents caused 34% of serious adverse drug reactions. The drug was discontinued in 71% of cases, at least temporarily. Adjusted hazard ratios for serious adverse drug reaction were significantly higher in patients with eGFR<30 versus ≥30 ml/min per 1.73 m2 (1.8; 95% confidence interval, 1.3 to 2.6), in those prescribed more than ten versus less than five medications (2.4; 95% confidence interval, 1.1 to 5.2), or in those with poor versus good adherence (1.6; 95% confidence interval, 1.4 to 2.4).Conclusions Adverse drug reactions are common and sometimes serious in patients with CKD. Many serious adverse drug reactions may be preventable. Some specific pharmacologic classes, particularly antithrombotic agents, are at risk of serious adverse drug reactions
dc.language.isoen
dc.publisherAmerican Society of Nephrology
dc.subject.enPharmacoepidemiology
dc.subject.enrenin-angiotensin system inhibitors
dc.subject.enantithrombotic agents
dc.subject.endiuretics
dc.subject.enchronic kidney disease
dc.subject.enadverse drug reaction
dc.title.enAdverse Drug Reactions in Patients with CKD
dc.typeArticle de revue
dc.identifier.doi10.2215/cjn.01030120
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Urologie et Néphrologie
bordeaux.journalClinical Journal of the American Society of Nephrology
bordeaux.page1090-1102
bordeaux.volume15
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue8
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-02958497
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02958497v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Clinical%20Journal%20of%20the%20American%20Society%20of%20Nephrology&amp;rft.date=2020&amp;rft.volume=15&amp;rft.issue=8&amp;rft.spage=1090-1102&amp;rft.epage=1090-1102&amp;rft.eissn=1555-9041&amp;rft.issn=1555-9041&amp;rft.au=LAVILLE,%20Sol%C3%A8ne&amp;GRAS-CHAMPEL,%20Val%C3%A9rie&amp;MORAGNY,%20Julien&amp;METZGER,%20Marie&amp;JACQUELINET,%20Christian&amp;rft.genre=article


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