Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors
hal.structure.identifier | Hôpital Pellegrin | |
dc.contributor.author | DUMAS DE LA ROQUE, C. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
hal.structure.identifier | Hôpital Pellegrin | |
hal.structure.identifier | CIC Bordeaux | |
dc.contributor.author | PREZELIN-REYDIT, Mathilde | |
hal.structure.identifier | Hôpital Pellegrin | |
dc.contributor.author | VERMOREL, A. | |
hal.structure.identifier | Hôpital Pellegrin | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
dc.contributor.author | LEPREUX, S. | |
dc.contributor.author | DEMINIERE, C. | |
hal.structure.identifier | Hôpital Pellegrin | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
dc.contributor.author | COMBE, C. | |
hal.structure.identifier | Hôpital Pellegrin | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
dc.contributor.author | RIGOTHIER, C. | |
dc.date.accessioned | 2021-06-10T07:03:20Z | |
dc.date.available | 2021-06-10T07:03:20Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/78910 | |
dc.description.abstractEn | There are various histopathological forms of idiopathic nephrotic syndrome, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Whereas some relapse predictor factors have been identified in renal transplantation, the clinical future of idiopathic nephrotic syndrome in the native kidney remains uncertain. We designed a multicentric retrospective descriptive cohort study including all patients aged 15 years and over whose renal biopsy confirmed MCD or FSGS between January 2007 and December 2014. We studied 165 patients with idiopathic nephrotic syndrome; 97 with MCD and 68 with FSGS. In the MCD cohort, 91.7% of patients were treated with corticosteroids for a median total duration of 13 months. During 45 months of follow-up, 92.8% of patients achieved remission and 45.5% experienced relapse. In this cohort, 5% of patients experienced terminal kidney disease. With respect to FSGS patients, 51.5% were treated with corticosteroids for a median total duration of 15 months. During 66 months of follow-up, 73.5% of patients achieved remission and 20% experienced relapse. In this cohort, 26.5% of patients experienced terminal kidney disease. No statistical association was observed between clinical and biological initial presentation and relapse occurrence. This study describes the characteristics of a cohort of patients with the nephrotic idiopathic syndromes of MCD and FSGS from the time of renal biopsy and throughout follow-up. | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.subject.en | idiopathic nephrotic syndrome | |
dc.subject.en | minimal change disease | |
dc.subject.en | focal segmental glomerulosclerosis | |
dc.subject.en | relapse | |
dc.subject.en | risk factors | |
dc.subject.en | complication | |
dc.title.en | Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors | |
dc.type | Article de revue | |
dc.identifier.doi | 10.3390/jcm7090265 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Urologie et Néphrologie | |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | |
bordeaux.journal | Journal of Clinical Medicine | |
bordeaux.page | 265 | |
bordeaux.volume | 7 | |
bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | * |
bordeaux.issue | 9 | |
bordeaux.institution | CNRS | |
bordeaux.institution | INSERM | |
bordeaux.institution | CHU de Bordeaux | |
bordeaux.institution | Institut Bergonié | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-03164706 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-03164706v1 | |
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