DAI, Michèle; GEORGILIS, Evangelos; GOUDOUNET, Guillaume; GARBAY, Bertrand; PILLE, Jan; VAN HEST, Jan C. M.; SCHULTZE, Xavier; GARANGER, Elisabeth; LECOMMANDOUX, Sebastien

doi:10.3390/polym13091470

DAI, Michèle
L'Oréal Recherche France [L'Oréal Recherche]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

GEORGILIS, Evangelos
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

GOUDOUNET, Guillaume
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Polymers. 2021-05-01, vol. 13, n° 9, p. 1470

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Diblock copolymers based-on elastin-like polypeptide (ELP) have the potential to undergo specific phase transitions when thermally stimulated. This ability is especially suitable to form carriers, micellar structures for instance, for delivering active cargo molecules. Here, we report the design and study of an ELP diblock library based on ELP-[M1V3-i]-[I-j]. First, ELP-[M1V3-i]-[I-j] (i = 20, 40, 60; j = 20, 90) that showed a similar self-assembly propensity (unimer-to-aggregate transition) as their related monoblocks ELP-[M1V3-i] and ELP-[I-j]. By selectively oxidizing methionines of ELP-[M1V3-i] within the different diblocks structures, we have been able to access a thermal phase transition with three distinct regimes (unimers, micelles, aggregates) characteristic of well-defined ELP diblocks.< Leer menos

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https://oskar-bordeaux.fr/handle/20.500.12278/78832

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http://dx.doi.org/10.3390/polym13091470

Proyecto europeo

Nanomedicine: an integrative approach

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Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Refining the Design of Diblock Elastin-Like Polypeptides for Self-Assembly into Nanoparticles

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DOI

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Centros de investigación