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dc.rights.licenseopenen_US
dc.contributor.authorFOUSSARD, N.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUGNARD-GREGOIRE, Audrey
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAJAOBELINA, Kalina
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cécile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLAMIREAU, Thierry
dc.contributor.authorGONZALEZ, C.
dc.contributor.authorGROUTHIER, V.
dc.contributor.authorHAISSAGUERRE, M.
dc.contributor.authorBLANCO, L.
dc.contributor.authorALEXANDRE, L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
dc.date.accessioned2020-06-10T14:58:23Z
dc.date.available2020-06-10T14:58:23Z
dc.date.issued2019-08
dc.identifier.issn1939-327X (Electronic) 0012-1797 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7868
dc.description.abstractEnAdvanced Glycation End-products (AGEs) accumulated during long-term hyperglycemia are involved in diabetes complications and can be estimated by skin Autofluorescence (sAF). During pregnancy, hyperglycemia exposes to the risk of having a macrosomic newborn. The aim of this study was to determine whether sAF of women with diabetes during a singleton pregnancy could predict macrosomia in their newborns. Using an AGE-Reader, we measured the sAF at the first visit of 343 women who were referred to our Diabetology department during years 2011-2015. Thirty-nine women had pregestational diabetes, 95 early Gestational Diabetes Mellitus (GDM) and 209 late GDM. Macrosomia was defined as birth weight >/=4000g and/or Large for Gestational Age (LGA) >/=90(th) centile. Forty-six newborns were macrosomic. Their mothers had +11% higher sAF compared to other mothers: 2.03+/-0.30 Arbitrary Unit (AU) vs 1.80+/-0.34 (p<0.0001). Using multivariate logistic regression, the relation between sAF and macrosomia was significant (OR: 4.13 for 1AU increase of sAF; 95%CI: 1.46-11.71) after adjusting for several potential confounders. This relation remained significant after further adjustment for HbA1c (among 263 women with available HbA1c), and for women with GDM only. sAF of pregnant women with diabetes, a marker of long-term hyperglycemic exposure, predicts macrosomia in their newborns.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enSkin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of Their Children
dc.typeArticle de revueen_US
dc.identifier.doi10.2337/db18-0906en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31127055en_US
bordeaux.journalDiabetesen_US
bordeaux.page1663-1669en_US
bordeaux.volume68en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03211509
hal.version1
hal.date.transferred2021-04-28T15:36:56Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Diabetes&amp;rft.date=2019-08&amp;rft.volume=68&amp;rft.issue=8&amp;rft.spage=1663-1669&amp;rft.epage=1663-1669&amp;rft.eissn=1939-327X%20(Electronic)%200012-1797%20(Linking)&amp;rft.issn=1939-327X%20(Electronic)%200012-1797%20(Linking)&amp;rft.au=FOUSSARD,%20N.&amp;COUGNARD-GREGOIRE,%20Audrey&amp;RAJAOBELINA,%20Kalina&amp;DELCOURT,%20C%C3%A9cile&amp;HELMER,%20Catherine&amp;rft.genre=article


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