Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid β-Peptide Aggregation.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | SYLLA, Tahiri | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | POUYSEGU, Laurent | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | DA COSTA, Gregory | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | DEFFIEUX, Denis | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | MONTI, Jean-Pierre | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | QUIDEAU, Stéphane | |
| dc.date.accessioned | 2021-05-21T16:11:48Z | |
| dc.date.available | 2021-05-21T16:11:48Z | |
| dc.date.issued | 2015-07-06 | |
| dc.identifier.issn | 1521-3773 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/78602 | |
| dc.description.abstractEn | The screening of natural products in the search for new lead compounds against Alzheimer's disease has unveiled several plant polyphenols that are capable of inhibiting the formation of toxic β-amyloid fibrils. Gallic acid based gallotannins are among these polyphenols, but their antifibrillogenic activity has thus far been examined using "tannic acid", a commercial mixture of gallotannins and other galloylated glucopyranoses. The first total syntheses of two true gallotannins, a hexagalloylglucopyranose and a decagalloylated compound whose structure is commonly used to depict "tannic acid", are now described. These depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid β-peptide (Aβ) aggregation in vitro, and monogalloylated α-glucogallin and a natural β-hexagalloylglucose are shown to be the strongest inhibitors. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Alzheimer Disease | |
| dc.subject.en | Amyloid beta-Peptides | |
| dc.subject.en | Gallic Acid | |
| dc.subject.en | Molecular Structure | |
| dc.subject.en | Polyphenols | |
| dc.subject.en | Tannins | |
| dc.title.en | Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid β-Peptide Aggregation. | |
| dc.title.alternative | Angew Chem Int Ed Engl | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/anie.201411606 | en_US |
| dc.identifier.pubmed | 26013280 | en_US |
| bordeaux.journal | Angewandte Chemie International Edition | en_US |
| bordeaux.page | 8217-21 | en_US |
| bordeaux.volume | 54 | en_US |
| bordeaux.hal.laboratories | Unité de Recherche Oenologie - EA 4577 | en_US |
| bordeaux.issue | 28 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.date=2015-07-06&rft.volume=54&rft.issue=28&rft.spage=8217-21&rft.epage=8217-21&rft.eissn=1521-3773&rft.issn=1521-3773&rft.au=SYLLA,%20Tahiri&POUYSEGU,%20Laurent&DA%20COSTA,%20Gregory&DEFFIEUX,%20Denis&MONTI,%20Jean-Pierre&rft.genre=article |
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