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A French multicentric prospective prognostic cohort with epidemiological, clinical, biological and treatment information to improve knowledge on lymphoma patients: study protocol of the “REal world dAta in LYmphoma and survival in adults” (REALYSA) cohort

dc.rights.licenseopenen_US
dc.contributor.authorGHESQUIERES, Herve
dc.contributor.authorROSSI, Cedric
dc.contributor.authorCHERBLANC, Fanny
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GUYADER-PEYROU, Sandra
dc.contributor.authorBIJOU, Fontanet
dc.contributor.authorSUJOBERT, Pierre
dc.contributor.authorFABBRO-PERAY, Pascale
dc.contributor.authorBERNIER, Adeline
dc.contributor.authorBELOT, Aurelien
dc.contributor.authorCHARTIER, Loic
dc.contributor.authorFORNECKER, Luc-Matthieu
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorBOUABDALLAH, Krimo
dc.contributor.authorLAURENT, Camille
dc.contributor.authorOBERIC, Lucie
dc.contributor.authorMORINEAU, Nadine
dc.contributor.authorLE GOUILL, Steven
dc.contributor.authorMORSCHHAUSER, Franck
dc.contributor.authorHAIOUN, Corinne
dc.contributor.authorDAMAJ, Gandhi
dc.contributor.authorGUIDEZ, Stephanie
dc.contributor.authorLABOURE, Gaelle
dc.contributor.authorFITOUSSI, Olivier
dc.contributor.authorLEBRAS, Laure
dc.contributor.authorGRESSIN, Remy
dc.contributor.authorSALLES, Gilles
dc.contributor.authorYSEBAERT, Loic
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.date.accessioned2021-05-20T13:56:47Z
dc.date.available2021-05-20T13:56:47Z
dc.date.issued2021-03-02
dc.identifier.issn1471-2458en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78596
dc.description.abstractEnBackground: Age-adjusted lymphoma incidence rates continue to rise in France since the early 80’s, although rates have slowed since 2010 and vary across subtypes. Recent improvements in patient survival in major lymphoma subtypes at population level raise new questions about patient outcomes (i.e. quality of life, long-term sequelae). Epidemiological studies have investigated factors related to lymphoma risk, but few have addressed the extent to which socioeconomic status, social institutional context (i.e. healthcare system), social relationships, environmental context (exposures), individual behaviours (lifestyle) or genetic determinants influence lymphoma outcomes, especially in the general population. Moreover, the knowledge of the disease behaviour mainly obtained from clinical trials data is partly biased because of patient selection. Methods: The REALYSA (“REal world dAta in LYmphoma and Survival in Adults”) study is a real-life multicentric cohort set up in French areas covered by population-based cancer registries to study the prognostic value of epidemiological, clinical and biological factors with a prospective 9-year follow-up. We aim to include 6000 patients over 4 to 5 years. Adult patients without lymphoma history and newly diagnosed with one of the following 7 lymphoma subtypes (diffuse large B-cell, follicular, marginal zone, mantle cell, Burkitt, Hodgkin, mature T-cell) are invited to participate during a medical consultation with their hematologist. Exclusion criteria are: having already received anti-lymphoma treatment (except pre-phase) and having a documented HIV infection. Patients are treated according to the standard practice in their center. Clinical data, including treatment received, are extracted from patients’ medical records. Patients’ risk factors exposures and other epidemiological data are obtained at baseline by filling out a questionnaire during an interview led by a clinical research assistant. Biological samples are collected at baseline and during treatment. A virtual tumor biobank is constituted for baseline tumor samples. Follow-up data, both clinical and epidemiological, are collected every 6 months in the first 3 years and every year thereafter. Discussion: This cohort constitutes an innovative platform for clinical, biological, epidemiological and socio-economic research projects and provides an opportunity to improve knowledge on factors associated to outcome of lymphoma patients in real life.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCohort study
dc.subject.enOutcomes
dc.subject.enLymphoma patients
dc.subject.enReal life
dc.subject.enFrance
dc.title.enA French multicentric prospective prognostic cohort with epidemiological, clinical, biological and treatment information to improve knowledge on lymphoma patients: study protocol of the “REal world dAta in LYmphoma and survival in adults” (REALYSA) cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12889-021-10433-4en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed33653294en_US
bordeaux.journalBMC Public Healthen_US
bordeaux.page432en_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierinserm-03218258
hal.version1
hal.exportfalse
workflow.import.sourcehal
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Public%20Health&rft.date=2021-03-02&rft.volume=21&rft.spage=432&rft.epage=432&rft.eissn=1471-2458&rft.issn=1471-2458&rft.au=GHESQUIERES,%20Herve&ROSSI,%20Cedric&CHERBLANC,%20Fanny&LE%20GUYADER-PEYROU,%20Sandra&BIJOU,%20Fontanet&rft.genre=article


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