Six-year survival study after myocardial infarction: The EOLE prospective cohort study. Long-term survival after MI
| dc.rights.license | open | en_US |
| dc.contributor.author | DROZ-PERROTEAU, C. | |
| dc.contributor.author | BLIN, Patrick | |
| dc.contributor.author | DUREAU-POURNIN, C. | |
| dc.contributor.author | THOMAS, D. | |
| dc.contributor.author | DANCHIN, N. | |
| dc.contributor.author | TRICOIRE, J. | |
| dc.contributor.author | PAILLARD, F. | |
| dc.contributor.author | HERCBERG, S. | |
| dc.contributor.author | GUIZE, L. | |
| dc.contributor.author | GUIARD, E. | |
| dc.contributor.author | MAIZI, H. | |
| dc.contributor.author | BERNARD, M. A. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BENICHOU, Jacques | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MOORE, Nicholas | |
| dc.date.accessioned | 2020-06-05T13:42:29Z | |
| dc.date.available | 2020-06-05T13:42:29Z | |
| dc.date.issued | 2019-09 | |
| dc.identifier.issn | 1958-5578 (Electronic) 0040-5957 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7790 | |
| dc.description.abstractEn | BACKGROUND: Studies of survival after myocardial infarction (MI) are often based on intention to treat analyses of controlled trials. OBJECTIVES: Describe long-term survival after MI in France. METHODS: Six-year cohort study of patients recruited within 3 months after MI. Primary outcome was all-cause death. Vital status was verified in the national death registry. Analysis used Cox models with time-dependent variables and propensity scores. RESULTS: Five thousand five hundred and twenty-seven (5527) subjects were included, 62.1+/-13 years old, 77.6% male, 9.6% smokers, 16.7% diabetic, 13.3% with previous MI. Up to 99% of patients were initially prescribed secondary prevention drugs (aspirin and/or other antiplatelet agents, beta-blockers, statins or other lipid-lowering agents, angiotensin converting enzyme inhibitors or angiotensin receptor blockers); 73% had all four classes. Overall 6-year mortality was 13.1% [95% confidence interval 12.3 to 14.0%], 2.34 per hundred patient-years (% PY); 49% returned all or all but one of the possible questionnaires (compliant [C]), 50.8% did not (non-compliant [NC]). The main predictors for death were non-compliance with study protocol (death rates NC 2.98% PY, C 1.69%PY, hazard ratio (HR) 3.13 [2.63-3.57]); increasing age at inclusion (HR up to 15.7 [10.7-23.2] for age >/=80); diabetes (1.39 [1.17-1.65]); smoking at inclusion (1.76 [1.27-2.44]), previous MI (1.46 [1.22-1.75]). Beta-blockers (0.79 [0.64-0.96]), statins (0.68 [0.51-0.90]), and enrolment in physical rehabilitation programs (0.74 [0.62-0.89]) were associated with a lower death rate. CONCLUSION: Association of mortality with non-compliance to study protocol probably indicates general non-compliance with prevention. Analyses of treatment effects were hindered by paucity of events and of unexposed patients. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | PharmacoEpi-Drugs | |
| dc.title.en | Six-year survival study after myocardial infarction: The EOLE prospective cohort study. Long-term survival after MI | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.therap.2019.02.001 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30878144 | en_US |
| bordeaux.journal | Thérapie | en_US |
| bordeaux.page | 459-468 | en_US |
| bordeaux.volume | 74 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03211507 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-28T15:35:40Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Th%C3%A9rapie&rft.date=2019-09&rft.volume=74&rft.issue=4&rft.spage=459-468&rft.epage=459-468&rft.eissn=1958-5578%20(Electronic)%200040-5957%20(Linking)&rft.issn=1958-5578%20(Electronic)%200040-5957%20(Linking)&rft.au=DROZ-PERROTEAU,%20C.&BLIN,%20Patrick&DUREAU-POURNIN,%20C.&THOMAS,%20D.&DANCHIN,%20N.&rft.genre=article |
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