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hal.structure.identifierInstitut de Recherche de l'Ecole Navale [IRENAV]
dc.contributor.authorHAN, Jing
dc.contributor.authorKESNER, Philip
dc.contributor.authorMETNA-LAURENT, Mathilde
dc.contributor.authorDUAN, Tingting
hal.structure.identifierKey Laboratory of Animal Models and Human Disease Mechanisms
dc.contributor.authorXU, Lin
dc.contributor.authorGEORGES, Francois
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendi
dc.contributor.authorKOEHL, Muriel
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorABROUS, Djoher Nora
dc.contributor.authorMENDIZABAL-ZUBIAGA, Juan
dc.contributor.authorGRANDES, Pedro
hal.structure.identifierHoméostasie cellulaire et cancer - Reprogrammation des réponses biologiques et thérapies alternatives [U1007]
dc.contributor.authorLIU, Qingsong
hal.structure.identifierONERA - The French Aerospace Lab [Châtillon]
dc.contributor.authorBAI, Guang
dc.contributor.authorWANG, Wei
hal.structure.identifierLaboratory of Learning and Memory
dc.contributor.authorXIONG, Lize
hal.structure.identifierShanghai Key Laboratory of Trustworthy Computing
dc.contributor.authorREN, Wei
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorMARSICANO, Giovanni
hal.structure.identifierInstitute of Environmental Assessment and Water Research [IDAEA]
dc.contributor.authorZHANG, Xia
dc.date.accessioned2021-05-14T09:57:25Z
dc.date.available2021-05-14T09:57:25Z
dc.date.issued2012-03-02
dc.identifier.issn0092-8674
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/77860
dc.description.abstractEnImpairment of working memory is one of the most important deleterious effects of marijuana intoxication in humans, but its underlying mechanisms are presently unknown. Here, we demonstrate that the impairment of spatial working memory (SWM) and in vivo long-term depression (LTD) of synaptic strength at hippocampal CA3-CA1 synapses, induced by an acute exposure of exogenous cannabinoids, is fully abolished in conditional mutant mice lacking type-1 cannabinoid receptors (CB(1)R) in brain astroglial cells but is conserved in mice lacking CB(1)R in glutamatergic or GABAergic neurons. Blockade of neuronal glutamate N-methyl-D-aspartate receptors (NMDAR) and of synaptic trafficking of glutamate α-amino-3-hydroxy-5-methyl-isoxazole propionic acid receptors (AMPAR) also abolishes cannabinoid effects on SWM and LTD induction and expression. We conclude that the impairment of working memory by marijuana and cannabinoids is due to the activation of astroglial CB(1)R and is associated with astroglia-dependent hippocampal LTD in vivo.
dc.language.isoen
dc.publisherElsevier
dc.title.enAcute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.cell.2012.01.037
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalCell
bordeaux.page1039-50
bordeaux.volume148
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295*
bordeaux.issue5
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.institutionArts et Métiers
bordeaux.institutionINSERM
bordeaux.peerReviewedoui
hal.identifierhal-01160047
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01160047v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell&rft.date=2012-03-02&rft.volume=148&rft.issue=5&rft.spage=1039-50&rft.epage=1039-50&rft.eissn=0092-8674&rft.issn=0092-8674&rft.au=HAN,%20Jing&KESNER,%20Philip&METNA-LAURENT,%20Mathilde&DUAN,%20Tingting&XU,%20Lin&rft.genre=article


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