Mapping of a gene for long QT syndrome to chromosome 4q25-27.
| hal.structure.identifier | ITX - unité de recherche de l'institut du thorax [ITX] | |
| dc.contributor.author | SCHOTT, J J | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie de Bordeaux [I2M] | |
| dc.contributor.author | CHARPENTIER, F | |
| hal.structure.identifier | Université de Poitiers = University of Poitiers [UP] | |
| dc.contributor.author | PELTIER, S | |
| hal.structure.identifier | Institut National de l'Environnement Industriel et des Risques [INERIS] | |
| dc.contributor.author | FOLEY, P | |
| hal.structure.identifier | Tumeurs endocrines digestives : mécanismes de la tumorigenèse et de la progression tumorale | |
| dc.contributor.author | DROUIN, E | |
| dc.contributor.author | BOUHOUR, J B | |
| dc.contributor.author | DONNELLY, P | |
| hal.structure.identifier | Institut de génétique et microbiologie [Orsay] [IGM] | |
| hal.structure.identifier | École Nationale Supérieure de Techniques Avancées [ENSTA Paris] | |
| dc.contributor.author | VERGNAUD, Gilles | |
| dc.contributor.author | BACHNER, L | |
| dc.contributor.author | MOISAN, J P | |
| dc.date.accessioned | 2021-05-14T09:57:24Z | |
| dc.date.available | 2021-05-14T09:57:24Z | |
| dc.date.issued | 1995-10-31 | |
| dc.identifier.issn | 0002-9297 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/77858 | |
| dc.description.abstractEn | Long QT syndrome (LQTS) is a heterogeneous inherited disorder causing syncope and sudden death from ventricular arrhythmias. A first locus for this disorder was mapped to chromosome 11p15.5. However, locus heterogeneity has been demonstrated in several families, and two other loci have recently been located on chromosomes 7q35-36 and 3p21-24. We used linkage analysis to map the locus in a 65-member family in which LQTS was associated with more marked sinus bradycardia than usual, leading to sinus node dysfunction. Linkage to chromosome 11p15.5, 7q35-36, or 3p21-24 was excluded. Positive linkage was obtained for markers located on chromosome 4q25-27. A maximal LOD score of 7.05 was found for marker D4S402. The identification of a fourth locus for LQTS confirms its genetic heterogeneity. Locus 4q25-27 is associated with a peculiar phenotype within the LQTS entity. | |
| dc.language.iso | en | |
| dc.publisher | Elsevier (Cell Press) | |
| dc.title.en | Mapping of a gene for long QT syndrome to chromosome 4q25-27. | |
| dc.type | Article de revue | |
| dc.subject.hal | Sciences du Vivant [q-bio] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | |
| bordeaux.journal | American Journal of Human Genetics | |
| bordeaux.page | 1114-22 | |
| bordeaux.volume | 57 | |
| bordeaux.hal.laboratories | Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295 | * |
| bordeaux.issue | 5 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.institution | INRAE | |
| bordeaux.institution | Arts et Métiers | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01160657 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01160657v1 | |
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