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Social deprivation is associated with poor kidney transplantation outcome in children

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDRIOLLET, Benedicte
dc.contributor.authorBAYER, F.
dc.contributor.authorCHATELET, V.
dc.contributor.authorMACHER, M. A.
dc.contributor.authorSALOMON, R.
dc.contributor.authorRANCHIN, B.
dc.contributor.authorROUSSEY, G.
dc.contributor.authorLAHOCHE, A.
dc.contributor.authorGARAIX, F.
dc.contributor.authorDECRAMER, S.
dc.contributor.authorMERIEAU, E.
dc.contributor.authorFILA, M.
dc.contributor.authorZALOSZYC, A.
dc.contributor.authorDESCHENES, G.
dc.contributor.authorVALERI, L.
dc.contributor.authorLAUNAY, L.
dc.contributor.authorCOUCHOUD, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.date.accessioned2020-06-05T10:58:29Z
dc.date.available2020-06-05T10:58:29Z
dc.date.issued2019-09
dc.identifier.issn0085-2538en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7772
dc.description.abstractEnSocioeconomic status is an important determinant of health. Its impact on kidney transplantation outcome has been studied among adults but data in children are scarce, especially in Europe. Here, we investigate the association between the level of social deprivation (determined by the continuous score European Deprivation Index) and graft failure risk in pediatric kidney transplant recipients. All patients listed under 18 years of age who received a first kidney transplant between 2002 and 2014 in France were included. Of 1050 kidney transplant recipients (males 59%, median age at transplantation 13.2 years, preemptive transplantation 23%), 211 graft failures occurred within a median followup of 5.9 years. Thirty-seven percent of these patients belong to the most deprived quintile, suggesting that deprivation is more frequent in pediatric patients with end-stage kidney disease (ESKD) than in the general population. Five- and ten-year graft survival were 85% and 69%, respectively, in the most deprived quintile vs. 90% and 83%, respectively, in the least deprived quintile. At any time after transplantation, patients in the most deprived quintile had almost a two-fold higher hazard of graft failure compared with the least deprived quintile, after adjustment for age at renal replacement therapy, duration of dialysis, primary kidney disease, and rural/urban living environment (hazard ratio 1.99; 95% confidence interval 1.20-3.28). The hazard of graft failure did not differ significantly between girls and boys. Thus, our findings suggest a lower socioeconomic status is independently associated with poor graft outcome in pediatric kidney transplantation.
dc.language.isoENen_US
dc.subject.enBiostatistics
dc.subject.enLEHA
dc.subject.enCIC1401
dc.title.enSocial deprivation is associated with poor kidney transplantation outcome in children
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.kint.2019.05.011en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31375259en_US
bordeaux.journalKidney Internationalen_US
bordeaux.page769-776en_US
bordeaux.volume96en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.teamBIOSTAT_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03211514
hal.version1
hal.date.transferred2021-04-28T15:38:42Z
hal.exporttrue
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