hal.structure.identifier | Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière [CRICM] | |
dc.contributor.author | CAROPPO, Paola | |
hal.structure.identifier | Laboratoire d'Imagerie Biomédicale [Paris] [LIB] | |
dc.contributor.author | HABERT, Marie-Odile | |
hal.structure.identifier | Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS] | |
dc.contributor.author | DURRLEMAN, Stanley | |
hal.structure.identifier | Neurosciences précliniques | |
dc.contributor.author | FUNKIEWIEZ, Aurélie | |
hal.structure.identifier | Laboratoire d'Imagerie Fonctionnelle [LIF] | |
dc.contributor.author | PERLBARG, Vincent | |
hal.structure.identifier | Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A] | |
dc.contributor.author | HAHN, Valérie | |
hal.structure.identifier | Transferts, écoulements, fluides, énergétique [TREFLE] | |
dc.contributor.author | BERTIN, Hugo | |
hal.structure.identifier | Laboratoire d'océanographie de Villefranche [LOV] | |
dc.contributor.author | GAUBERT, Malo | |
hal.structure.identifier | Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS] | |
dc.contributor.author | ROUTIER, Alexandre | |
hal.structure.identifier | Génétique du cancer et des maladies neuropsychiatriques [GMFC] | |
dc.contributor.author | HANNEQUIN, Didier | |
hal.structure.identifier | Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV] | |
dc.contributor.author | DERAMECOURT, Vincent | |
hal.structure.identifier | Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV] | |
dc.contributor.author | PASQUIER, Florence | |
hal.structure.identifier | Neurologie et thérapeutique expérimentale | |
dc.contributor.author | RIVAUD-PECHOUX, Sophie | |
hal.structure.identifier | Service de neurologie [Nantes] | |
dc.contributor.author | VERCELLETTO, Martine | |
hal.structure.identifier | Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A] | |
dc.contributor.author | EDOUART, Geoffrey | |
hal.structure.identifier | Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM] | |
dc.contributor.author | VALABREGUE, Romain | |
hal.structure.identifier | Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A] | |
dc.contributor.author | LEJEUNE, Pascal | |
hal.structure.identifier | Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A] | |
dc.contributor.author | DIDIC, Mira | |
hal.structure.identifier | Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM] | |
dc.contributor.author | CORVOL, Jean-Christophe | |
hal.structure.identifier | Laboratoire d'Imagerie Biomédicale [Paris] [LIB] | |
dc.contributor.author | BENALI, Habib | |
hal.structure.identifier | Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM] | |
dc.contributor.author | LEHÉRICY, Stéphane | |
hal.structure.identifier | Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A] | |
dc.contributor.author | DUBOIS, Bruno | |
hal.structure.identifier | Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS] | |
dc.contributor.author | COLLIOT, Olivier | |
hal.structure.identifier | Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM] | |
dc.contributor.author | BRICE, Alexis | |
hal.structure.identifier | Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière [CRICM] | |
hal.structure.identifier | CHU Pitié-Salpêtrière [AP-HP] | |
dc.contributor.author | LE BER, Isabelle | |
dc.date.accessioned | 2021-05-14T09:54:47Z | |
dc.date.available | 2021-05-14T09:54:47Z | |
dc.date.issued | 2015-08 | |
dc.identifier.issn | 1387-2877 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/77645 | |
dc.description.abstractEn | The preclinical stage of frontotemporal lobar degeneration (FTLD) is not well characterized. We conducted a brain metabolism (FDG-PET) and structural (cortical thickness) study to detect early changes in asymptomatic GRN mutation carriers (aGRN+) that were evaluated longitudinally over a 20-month period. At baseline, a left lateral temporal lobe hypometabolism was present in aGRN+ without any structural changes. Importantly, this is the first longitudinal study and, across time, the metabolism more rapidly decreased in aGRN+ in lateral temporal and frontal regions. The main structural change observed in the longitudinal study was a reduction of cortical thickness in the left lateral temporal lobe in carriers. A limit of this study is the relatively small sample (n = 16); nevertheless, it provides important results. First, it evidences that the pathological processes develop a long time before clinical onset, and that early neuroimaging changes might be detected approximately 20 years before the clinical onset of disease. Second, it suggests that metabolic changes are detectable before structural modifications and cognitive deficits. Third, both the baseline and longitudinal studies provide converging results implicating lateral temporal lobe as early involved in GRN disease. Finally, our study demonstrates that structural and metabolic changes could represent possible biomarkers to monitor the progression of disease in the presymptomatic stage toward clinical onset. | |
dc.language.iso | en | |
dc.publisher | IOS Press | |
dc.subject.en | frontotemporal lobar degeneration | |
dc.subject.en | frontotemporal dementia | |
dc.subject.en | dementia | |
dc.subject.en | PET | |
dc.subject.en | GRN | |
dc.subject.en | preclinical study | |
dc.subject.en | longitudinal | |
dc.subject.en | Cortical thickness | |
dc.subject.en | presymptomatic | |
dc.subject.en | progranulin | |
dc.title.en | Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease? | |
dc.type | Article de revue | |
dc.identifier.doi | 10.3233/JAD-150270 | |
dc.subject.hal | Sciences de l'ingénieur [physics]/Traitement du signal et de l'image | |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie | |
bordeaux.journal | Journal of Alzheimer's Disease | |
bordeaux.page | 751-9 | |
bordeaux.volume | 47 | |
bordeaux.hal.laboratories | Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295 | * |
bordeaux.issue | 3 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.institution | INRAE | |
bordeaux.institution | Arts et Métiers | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01220380 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01220380v1 | |
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