Mostrar el registro sencillo del ítem

The prognostic value of G8 for functional decline

dc.rights.licenseopenen_US
dc.contributor.authorCHAKIBA, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELLERA, Carine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorETCHEPARE, Fanny
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN-PELISSIER, Simone
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAINFRAY, Muriel
dc.contributor.authorSOUBEYRAN, P.
dc.date.accessioned2020-06-04T08:51:36Z
dc.date.available2020-06-04T08:51:36Z
dc.date.issued2019
dc.identifier.issn1879-4076 (Electronic) 1879-4068 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7741
dc.description.abstractEnPURPOSE: Clinical experience suggests that functional decline (FD) during treatment may have a major adverse impact on outcome. Geriatric assessment of older patients before cancer treatment is usually based on use of a screening tool (such as G8) followed by comprehensive geriatric assessment (CGA). However, many oncology teams cannot implement geriatric oncology management due to non-availability of geriatricians. Consequently, we decided to evaluate whether a procedure using G8 and routinely available factors could help oncologists foresee the outcome in patients >/=70: we firstly evaluated whether functional decline is a determinant of early death, then searched for predictors of early functional decline (measured before initiation of the second cycle of chemotherapy), including G8 but voluntarilly excluding CGA. METHODS: We tested the value of clinical, biological factors and early FD to predict early death on a cohort of 292 patients (>/=70years) treated with first-line chemotherapy. We then used a logistic regression model to search for pretreatment predictors of FD, including the same factors and G8 but excluding CGA. RESULTS: FD occurred in 48 patients. In multivariate analyses, early FD (OR=4.13, 95% CI [1.89; 9.04], p<.01), disease extension (OR=4.55, 95% CI [1.96; 10.57]; p<.01), and being male (OR=2.59, 95% CI [1.12; 5.97], p =.02) were significant prognostic factors for early death; G8 was the only significant factor associated with FD (OR=4.38, 95% CI [1.28; 14.92], p=.018). CONCLUSIONS: FD has an important prognostic significance in patients >/=70 treated with chemotherapy, and G8 predicts for its occurrence. These data reinforce the routine use of G8 in the management of these patients.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enThe prognostic value of G8 for functional decline
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jgo.2018.12.004en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30638869en_US
bordeaux.journalJournal of Geriatric Oncologyen_US
bordeaux.page921-925en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03212192
hal.version1
hal.date.transferred2021-04-29T11:57:57Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Geriatric%20Oncology&amp;rft.date=2019&amp;rft.volume=10&amp;rft.issue=6&amp;rft.spage=921-925&amp;rft.epage=921-925&amp;rft.eissn=1879-4076%20(Electronic)%201879-4068%20(Linking)&amp;rft.issn=1879-4076%20(Electronic)%201879-4068%20(Linking)&amp;rft.au=CHAKIBA,%20C.&amp;BELLERA,%20Carine&amp;ETCHEPARE,%20Fanny&amp;MATHOULIN-PELISSIER,%20Simone&amp;RAINFRAY,%20Muriel&amp;rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem