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Hepatitis B virus activity in untreated hepatitis B e antigen-negative human immunodeficiency virus-hepatitis B virus co-infected patients from sub-Saharan Africa

dc.rights.licenseopenen_US
dc.contributor.authorBOYD, A.
dc.contributor.authorKOUAME, Menan Gerard
dc.contributor.authorHOUGHTALING, L.
dc.contributor.authorMOH, Desmorys Raoul
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGABILLARD, Delphine
dc.contributor.authorMAYLIN, S.
dc.contributor.authorCHEKARAOU, M. A.
dc.contributor.authorDELAUGERRE, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorANGLARET, Xavier
dc.contributor.authorEHOLIE, S. P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDANEL, Christine
dc.contributor.authorZOULIM, F.
dc.contributor.authorLACOMBE, K.
dc.date.accessioned2020-06-03T11:47:38Z
dc.date.available2020-06-03T11:47:38Z
dc.date.issued2019
dc.identifier.issn0035-9203en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7718
dc.description.abstractEnBackground In human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients from sub-Saharan Africa with hepatitis B e antigen (HBeAg)-negative status, data are limited on the evolution of HBV activity when antiretroviral treatment (ART) is absent. Methods A total of 43 HBeAg-negative co-infected patients not indicated for ART (per concomitant World Health Organization recommendations) were followed during participation in a randomized controlled trial in Cote d'Ivoire. Chronic HBeAg-negative phases were classified at yearly visits and defined as infection' (HBV DNA <= 10 000 copies/mL and normal alanine aminotransferase [ALT]) or hepatitis' (HBV DNA >10 000 copies/mL and/or above normal ALT). Dispersion in HBV DNA and ALT levels during follow-up was assessed using interquartile range (IQR) regression. Results During a median 25 months (IQR 19-31), 17 (40%) patients consistently had infection', 5 (12%) consistently had hepatitis' and 21 (48%) fluctuated between phases. Wider dispersion in HBV DNA over time was associated with higher baseline HIV RNA (p=0.02) and higher baseline HBV DNA levels (p=0.008), while wider dispersion in ALT was associated with higher baseline HIV RNA (p<0.001), higher baseline ALT levels (p=0.02) and baseline hepatitis surface antigen >4.0 log(10) IU/mL (p=0.02). Conclusions HBV activity is common with HBeAg-negative status, whose variation is partly linked to HIV replication. Fluctuations in disease phase make it difficult to assess the risk of morbidity and mortality after ART initiation.
dc.language.isoENen_US
dc.subject.enIDLIC
dc.title.enHepatitis B virus activity in untreated hepatitis B e antigen-negative human immunodeficiency virus-hepatitis B virus co-infected patients from sub-Saharan Africa
dc.title.alternativeTransactions of the Royal Society of Tropical Medicine and Hygieneen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/trstmh/trz021en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalTransactions of The Royal Society of Tropical Medicine and Hygieneen_US
bordeaux.page437-445en_US
bordeaux.volume113en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.identifierhal-03209864
hal.version1
hal.date.transferred2021-04-27T13:04:59Z
hal.exporttrue
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