JIANG, Jian-Qiao; CHANSEAU, Christel; ALVES, Isabel; NLATE, Sylvain; DURRIEU, Marie-Christine

doi:10.1016/j.isci.2019.10.014

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JIANG, Jian-Qiao
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

CHANSEAU, Christel
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

ALVES, Isabel

Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

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iScience. 2019, vol. 21, p. 110-123

Résumé en anglais

Microvesicles (MVs) are used by various types of cells in the human body for intercellular communication, making them biomarkers of great potential for the early and non-evasive diagnosis of a spectrum of diseases. An integrated analysis including morphological, quantitative, and compositional studies is most desirable for the clinical application of MV detection; however, such integration is limited by the currently available analysis techniques. In this context, exploiting the phosphatidylserine (PS) exposure of MVs, we synthesized a series of dendritic molecules with PS-binding sites at the periphery. PS-dendron binding was studied at the molecular level using NMR approaches, whereas PS-containing membrane-dendron interaction was investigated in an aqueous environment using plasmon waveguide resonance spectroscopy. As a proof of concept, polyethylene terephthalate surface was functionalized with the synthetic dendrons, forming devices that can capture MVs to facilitate their subsequent analyses.< Réduire

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Chemistry

Supramolecular Chemistry

Surface Science

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Dendron-Functionalized Surface: Efficient Strategy for Enhancing the Capture of Microvesicles

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