Body composition and adipokines changes after initial treatment with darunavir-ritonavir plus either raltegravir or tenofovir disoproxil fumarate-emtricitabine: A substudy of the NEAT001/ANRS143 randomised trial
dc.rights.license | open | en_US |
dc.contributor.author | BERNARDINO, J. I. | |
dc.contributor.author | MOCROFT, A. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | WALLET, Cedrick | |
dc.contributor.author | DE WIT, S. | |
dc.contributor.author | KATLAMA, C. | |
dc.contributor.author | REISS, P. | |
dc.contributor.author | MALLON, P. W. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | RICHERT, Laura | |
dc.contributor.author | MOLINA, J. M. | |
dc.contributor.author | KNOBEL, H. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | MORLAT, Philippe | |
dc.contributor.author | BABIKER, A. | |
dc.contributor.author | POZNIAC, A. | |
dc.contributor.author | RAFFI, F. | |
dc.contributor.author | ARRIBAS, J. R. | |
dc.date.accessioned | 2020-05-15T09:03:42Z | |
dc.date.available | 2020-05-15T09:03:42Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1932-6203 (Electronic) 1932-6203 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7583 | |
dc.description.abstractEn | BACKGROUND: Comparison of changes in body composition, adipokines and inflammatory markers after initial therapy with a nucleos(t)ide reverse transcriptase inhibitor (N(t)RTI)- sparing or containing regimen are scarce. DESIGN: Randomised Clinical Trial. METHODS: This is the body composition substudy of NEAT 001/ANRS 143, a randomised trial comparing darunavir/ritonavir (DRV/r) plus either raltegravir (RAL) or tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) in 805 ART naive HIV-infected adults. The primary endpoint was percentage change in limb fat at week 96. Secondary endpoints were associations among these changes and metabolic markers (IL-6, insulin, leptin, adiponectin, FGF-23). RESULTS: 126 subjects (61 DRV/r + RAL and 65 DRV/r + TDF/FTC) were included. The rate of change in BMI between groups for RAL versus TDF/FTC at week 96 was 1.5% per 48-week period (p = 0.015). The rate of change in limb fat mass, trunk fat mass, total body fat and total lean mass was for RAL versus TDF/FTC at week 96 was 2.5% (p = 0.38), 7.3% ((p = 0.021), 4.9% (p = 0.061) and 1.3% (p = 0.12) respectively. Baseline insulin and leptin levels were correlated with baseline limb fat and trunk fat mass [r = 0.31 (p = 0.0043)/r = 0.28 (p = 0.0011) for limb fat, and r = 0.63 (p<0.0001)/r = 0.50(p<0.0001) for trunk fat]. After adjustment, a 10% faster increase in leptin between baseline and week 48 was associated with a more rapid increase in limb fat at week 48 (0.5% per 48 weeks, p<0.001), total body fat mass (0.6% per 48 weeks, p<0.001), and trunk fat mass (0.3% per 48 weeks, p = 0.0026). CONCLUSIONS: After week 96 a N(t)RTI sparing regimen of DRV/r + RAL produced a numerically greater percentage increase in body composition variables with only change in trunk fat mass and BMI being significant. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/us/ | |
dc.subject.en | SISTM | |
dc.subject.en | MORPH3Eus | |
dc.subject.en | FR | |
dc.title.en | Body composition and adipokines changes after initial treatment with darunavir-ritonavir plus either raltegravir or tenofovir disoproxil fumarate-emtricitabine: A substudy of the NEAT001/ANRS143 randomised trial | |
dc.title.alternative | PLoS One | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1371/journal.pone.0209911 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 30689664 | en_US |
dc.description.sponsorshipEurope | European AIDS Treatment Network | en_US |
bordeaux.journal | PLoS ONE | en_US |
bordeaux.page | e0209911 | en_US |
bordeaux.volume | 14 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
bordeaux.issue | 1 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.team | SISTM_BPH | |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.export | false | |
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