Parallel homochiral and anti-parallel heterochiral hydrogen-bonding interfaces in multi-helical abiotic foldamers
Language
EN
Article de revue
This item was published in
Angewandte Chemie (International ed. in English). 2019, vol. 59, n° 4, p. 1606-1610
English Abstract
A hydrogen-bonding interface between helical aromatic oligoamide foldamers has been designed to promote the folding of a helix-turn-helix motif with a head-to-tail arrangement of two helices of opposite handedness. This ...Read more >
A hydrogen-bonding interface between helical aromatic oligoamide foldamers has been designed to promote the folding of a helix-turn-helix motif with a head-to-tail arrangement of two helices of opposite handedness. This design complements an earlier helix-turn-helix motif with a head-to-head arrangement of two helices of identical handedness interface. The two motifs were shown to have comparable stability and were combined in a unimolecular tetra-helix fold constituting the largest abiotic tertiary structure to date.Read less <
English Keywords
foldamers
helix bundles
molecular design
structure elucidation
tertiary structures