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Effects of Malaria in the First Trimester of Pregnancy on Poor Maternal and Birth Outcomes in Benin

dc.rights.licenseopenen_US
dc.contributor.authorACCROMBESSI, M.
dc.contributor.authorYOVO, E.
dc.contributor.authorFIEVET, N.
dc.contributor.authorCOTTRELL, G.
dc.contributor.authorAGBOTA, G.
dc.contributor.authorGARTNER, A.
dc.contributor.authorMARTIN-PREVEL, Y.
dc.contributor.authorVIANOU, B.
dc.contributor.authorSOSSOU, D.
dc.contributor.authorFANOU-FOGNY, N.
dc.contributor.authorDJOSSINOU, D.
dc.contributor.authorMASSOUGBODJI, A.
dc.contributor.authorCOT, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBRIAND, Valerie
dc.date.accessioned2020-05-06T13:11:30Z
dc.date.available2020-05-06T13:11:30Z
dc.date.issued2019
dc.identifier.issn1537-6591 (Electronic) 1058-4838 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7487
dc.description.abstractEnBackground: In sub-Saharan Africa, malaria in the first half of pregnancy is harmful for both the mother and her foetus. However, malaria in the 1st trimester of pregnancy, when women are usually not protected against malaria, has been little investigated. For the first time, we assessed the effects of malaria in the 1st trimester on maternal and birth outcomes using a preconceptional study design. Methods: From June 2014 to March 2017, 1214 women of reproductive age were recruited and followed monthly until 411 became pregnant. Pregnant women were then followed from 5-6 weeks of gestation until delivery. Path analysis was used to assess the direct effect (i.e., not mediated by malaria in the 2nd or 3rd trimester) of malaria in the 1st trimester on maternal anaemia and poor birth outcomes. The cumulative effect of infections during pregnancy on the same outcomes was also evaluated. Results: The prevalence of malaria infection in the 1st trimester was 21.8%. Malaria in the 1st trimester was significantly associated with maternal anaemia in the 3rd trimester (adjusted odds ratio [aOR]: 2.25, 95% CI 1.11, 4.55). While we did not evidence any direct effect of 1st trimester malaria infections on birth outcomes, their association with infections later in pregnancy tended to increase the risk of low birthweight. Conclusions : alaria infections in the 1st trimester were highly prevalent and have deleterious effects on maternal anaemia. They highlight the need for additional preventive measures starting in early pregnancy, or even before conception.
dc.language.isoENen_US
dc.subject.enIDLIC
dc.title.enEffects of Malaria in the First Trimester of Pregnancy on Poor Maternal and Birth Outcomes in Benin
dc.title.alternativeClin Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cid/ciy1073en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30561538en_US
bordeaux.journalClinical Infectious Diseasesen_US
bordeaux.page1385-1393en_US
bordeaux.volume69en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209512
hal.version1
hal.date.transferred2021-04-27T09:38:38Z
hal.exporttrue
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