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Kidney Transplantation in Small Children: Association Between Body Weight and Outcome - A Report From the ESPN/ERA-EDTA Registry

dc.rights.licenseopenen_US
dc.contributor.authorBOEHM, Michael
dc.contributor.authorBONTHUIS, Marjolein
dc.contributor.authorAUFRICHT, Christoph
dc.contributor.authorBATTELINO, Nina
dc.contributor.authorBJERRE, Anna
dc.contributor.authorEDVARDSSON, Vidar O.
dc.contributor.authorHERTHELIUS, Maria
dc.contributor.authorHUBMANN, Holger
dc.contributor.authorJAHNUKAINEN, Timo
dc.contributor.authorDE JONG, Huib
dc.contributor.authorLAUBE, Guido F.
dc.contributor.authorMATTOZZI, Francesca
dc.contributor.authorMOLCHANOVA, Elena A.
dc.contributor.authorMUNOZ, Marina
dc.contributor.authorNOYAN, Aytul
dc.contributor.authorPAPE, Lars
dc.contributor.authorPRINTZA, Nikoleta
dc.contributor.authorREUSZ, George
dc.contributor.authorROUSSEY, Gwenaelle
dc.contributor.authorRUBIK, Jacek
dc.contributor.authorSPASOJEVIC-DIMITRIJEVA, Brankica
dc.contributor.authorSEEMAN, Tomas
dc.contributor.authorWARE, Nicholas
dc.contributor.authorVIDAL, Enrico
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorJAGER, Kitty J.
dc.contributor.authorGROOTHOFF, Jaap
dc.date.accessioned2021-05-12T14:37:47Z
dc.date.available2021-05-12T14:37:47Z
dc.date.issued2021-03-26
dc.identifier.issn0041-1337en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/74550
dc.description.abstractEnBackground: Many centers accept a minimum body weight of 10 kg as threshold for kidney transplantation (Tx) in children. As solid evidence for clinical outcomes in multinational studies is lacking, we evaluated practices and outcomes in European children weighing below 10 kg at Tx. Methods: Data were obtained from the ESPN/ERA-EDTA Registry on all children who started kidney replacement therapy (KRT) at <2.5 years of age and received a Tx between 2000 and 2016. Weight at Tx was categorized (<10 kg versus ≥10 kg) and Cox regression analysis was used to evaluate its association with graft survival. Results: One hundred of the 601 children received a Tx below a weight of 10 kg during the study period. Primary renal disease groups were equal, but Tx <10 kg patients had lower pre-Tx weight gain per year (0.2 kg versus 2.1 kg; p<0.001) and had a higher preemptive Tx rate (23% versus 7%; p<0.001). No differences were found for posttransplant estimated glomerular filtration rates (eGFR) trajectories (p=0.23). The graft failure risk was higher in Tx <10 kg patients at 1 year (graft survival: 90% versus 95%; aHR: 3.84, 95% CI: 1.24-11.84), but not at 5 years (aHR: 1.71, 95% CI: 0.68-4.30). Conclusions: Despite a lower 1-year graft survival rate, graft function and survival at 5 years were identical in Tx <10 kg patients when compared with Tx ≥10 kg patients. Our results suggest that early transplantation should be offered to a carefully selected group of patients weighing <10 kg.
dc.language.isoENen_US
dc.title.enKidney Transplantation in Small Children: Association Between Body Weight and Outcome - A Report From the ESPN/ERA-EDTA Registry
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/tp.0000000000003771en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33795596en_US
bordeaux.journalTransplantationen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03225565
hal.version1
hal.date.transferred2021-05-12T14:37:51Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Transplantation&amp;rft.date=2021-03-26&amp;rft.eissn=0041-1337&amp;rft.issn=0041-1337&amp;rft.au=BOEHM,%20Michael&amp;BONTHUIS,%20Marjolein&amp;AUFRICHT,%20Christoph&amp;BATTELINO,%20Nina&amp;BJERRE,%20Anna&amp;rft.genre=article


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