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Caveolae-mediated effects of TNF-alpha on human skeletal muscle cells

dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDARGELOS, Elise
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorRENAUD, Valentine
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDECOSSAS, Marion
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBURE, Corinne
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAMBERT, Olivier
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorPOUSSARD, Sylvie
dc.date.accessioned2020-04-15T12:24:34Z
dc.date.available2020-04-15T12:24:34Z
dc.date.issued2018
dc.identifier.issn0014-4827en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/4277
dc.description.abstractEnChronic diseases are characterized by the production of pro-inflammatory cytokines such than TNF-alpha and are frequently correlated with muscle wasting conditions. Among the pleiotropic effects of TNF-alpha within the cell, its binding to TNFR1 receptor has been shown to activate sphingomyelinases leading to the production of ceramides. Sphingomyelinases and TNF receptor have been localized within caveolae which are specialized RAFT enriched in cholesterol and sphingolipids. Because of their inverted omega shape, maintained by the oligomerization of specialized proteins, caveolins and cavins, caveolae serve as membrane reservoir therefore providing mechanical protection to plasma membranes. Although sphingolipids metabolites, caveolins and TNF-alpha/TNFR1 have been shown to independently interfere with muscle physiology, no data have clearly demonstrated their concerted action on muscle cell regeneration. In this context, our study aimed at studying the molecular mechanisms induced by TNF-alpha at the level of caveolae in LHCN-M2 human muscle satellite cells. Here we showed that TNF-alpha-induced production of ROS and nSMase activation requires caveolin. More strikingly, we have demonstrated that TNF-alpha induces the formation of additional caveolae at the plasma membrane of myoblasts. Furthermore, TNF-alpha prevents myoblast fusion suggesting that inflammation could modulate caveolae organization/function and satellite cell function.
dc.language.isoENen_US
dc.subject.enCaveolae
dc.subject.enMyoblasts
dc.subject.enInflammation
dc.subject.enTNF-α
dc.subject.enOxidative stress
dc.subject.enSphingomyelinase
dc.title.enCaveolae-mediated effects of TNF-alpha on human skeletal muscle cells
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.yexcr.2018.07.027en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalExperimental Cell Researchen_US
bordeaux.page623-631en_US
bordeaux.volume370en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.issue2en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02543571
hal.version1
hal.date.transferred2020-04-15T12:24:38Z
hal.exporttrue
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