Oral administration of lipid oil-in-water emulsions performed with synthetic or protein-type emulsifiers differentially affects post-prandial triacylglycerolemia in rats
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | NASSRA, Merian | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BOURGEOIS, Christine | |
| dc.contributor.author | SUBIRADE, Muriel | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | SAUVANT, Patrick
ORCID: 0000-0002-2562-9185 IDREF: 118627325 | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | ATGIE, Claude
IDREF: 097463213 | |
| dc.date.accessioned | 2020-04-09T09:33:01Z | |
| dc.date.available | 2020-04-09T09:33:01Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 1138-7548 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/4195 | |
| dc.description.abstractEn | In this study, we compared the impact of administration of size-calibrated lipid emulsions prepared with either synthetic or natural emulsifiers on the post-absorptive plasma triacylglycerol responses in rats. We did this using four types of size-calibrated (10mum diameter) and metastable (3days) emulsions with 20% of an oleic acid-rich sunflower oil and 1% of either synthetic emulsifiers (Tween 80 or sodium 2-stearoyl-lactylate) or two proteins (beta-lactoglobulin or sodium caseinate). An oral fat tolerance test was performed in fasted rats by oral administration of each of these formulations in continuous or emulsified forms. Kinetic parameters (AUC0-inf., AUC0-6h, Cmax, Tmax, and T1/2) for the description of the plasma triacylglycerol responses were calculated. AUC0-6h and AUC0-inf. calculated for the protein groups were significantly lower than those of the control and the synthetic groups. These lower values were associated with significant decreases in the Cmax, exacerbated by the emulsion form and with marked decreases in the Tmax as compared to the control group. T1/2 values were differentially affected by the lipid administration forms and by the nature of the emulsifiers. As compared with the control group, T1/2 was largely increased in the sodium stearoyl-2-lactylate group, but on the contrary, largely lowered in the casein group. We concluded that the use of proteins as natural emulsifiers in lipid emulsions decreased the magnitude of post-prandial triacylglycerolemia for the same amount of ingested lipids, when the emulsion size is controlled for. Proteins could be a promising alternative to the widespread use of synthetic emulsifiers in the food industry. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Food | |
| dc.subject.en | Tween 80 | |
| dc.subject.en | Sodium-2-stearoyl lactylate | |
| dc.subject.en | β-lactoglobulin | |
| dc.subject.en | Sodium caseinate | |
| dc.subject.en | Oral fat tolerance test | |
| dc.subject.en | Triacylglycerol | |
| dc.title.en | Oral administration of lipid oil-in-water emulsions performed with synthetic or protein-type emulsifiers differentially affects post-prandial triacylglycerolemia in rats | |
| dc.title.alternative | J Physiol Biochem | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s13105-018-0634-0 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | Journal of physiology and biochemistry | en_US |
| bordeaux.page | 603-612 | en_US |
| bordeaux.volume | 74 | en_US |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-02538132 | |
| hal.version | 1 | |
| hal.date.transferred | 2020-04-09T09:33:07Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20physiology%20and%20biochemistry&rft.date=2018&rft.volume=74&rft.issue=4&rft.spage=603-612&rft.epage=603-612&rft.eissn=1138-7548&rft.issn=1138-7548&rft.au=NASSRA,%20Merian&BOURGEOIS,%20Christine&SUBIRADE,%20Muriel&SAUVANT,%20Patrick&ATGIE,%20Claude&rft.genre=article |
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