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dc.rights.licenseopenen_US
dc.contributor.authorLABIE, Hélène
dc.contributor.authorPERRO, Adeline
dc.contributor.authorLAPEYRE, Véronique
dc.contributor.authorGOUDEAU, Bertrand
dc.contributor.authorCATARGI, Bogdan
dc.contributor.authorAUZÉLY, Rachel
dc.contributor.authorRAVAINE, Valérie
dc.date.accessioned2019
dc.date.available2019
dc.date.issued2019
dc.identifier.issn0021-9797en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/3830
dc.description.abstractEnA simple route to deliver on demand hydrosoluble molecules such as peptides, packaged in biocompatible and biodegradable microgels, is presented. Hyaluronic acid hydrogel particles with a controlled structure are prepared using a microfluidic approach. Their porosity and their rigidity can be tuned by changing the crosslinking density. These negatively-charged polyelectrolytes interact strongly with positively-charged linear peptides such as poly-l-lysine (PLL). Their interactions induce microgel deswelling and inhibit microgel enzymatic degradability by hyaluronidase. While small PLL penetrate the whole volume of the microgel, PLL larger than the mesh size of the network remain confined at its periphery. They make a complexed layer with reduced pore size, which insulates the microgel inner core from the outer medium. Consequently, enzymatic degradation of the matrix is fully inhibited and non-affinity hydrophilic species can be trapped in the core. Indeed, negatively-charged or small neutral peptides, without interactions with the network, usually diffuse freely across the network. By simple addition of large PLL, they are packaged in the core and can be released on demand, upon introduction of an enzyme that degrades selectively the capping agent. Single polyelectrolyte layer appears as a simple generic method to coat hydrogel-based materials of various scales for encapsulation and controlled delivery of hydrosoluble molecules.
dc.language.isoENen_US
dc.subject.enDrug delivery
dc.subject.enMicrogels
dc.subject.enHyaluronic acid
dc.subject.enElectrostatic complexation
dc.subject.enInsulin
dc.subject.enCore-shell particle
dc.title.enSealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release
dc.title.alternativeJournal of Colloid and Interface Scienceen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jcis.2018.09.048en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalJournal of Colloid and Interface Scienceen_US
bordeaux.page16-27en_US
bordeaux.volume535en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02509880
hal.version1
hal.date.transferred2020-03-17T10:43:30Z
hal.exporttrue
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