Robust and adaptive anticoagulant control
CLAIRON, Quentin
Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]
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Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]
CLAIRON, Quentin
Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]
< Reduce
Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]
Language
EN
Article de revue
This item was published in
Journal of the Royal Statistical Society: Series C Applied Statistics. 2020-06, vol. 69, n° 3, p. 503-524
English Abstract
We consider a control theory approach to adaptive dose allocation of anticoagulants, based on an analysis of records of 152 patients on long-term warfarin treatment. We consider a selection of statistical models for the ...Read more >
We consider a control theory approach to adaptive dose allocation of anticoagulants, based on an analysis of records of 152 patients on long-term warfarin treatment. We consider a selection of statistical models for the relationship between the dose of drug and subsequent blood clotting speed, measured through the international normalized ratio. Our main focus is on subsequent use of the model in guiding the choice of the next dose adaptively as patient-specific information accrues. We compare a naive long-term approach with a proportional-integral-plus method, with parameters estimated by either linear quadratic optimization or by stochastic resource allocation. We demonstrate advantages of the control approaches in comparison with a naive approach in simulations and through calculation of robust stability margins for the observed dataRead less <
English Keywords
Controller design
Deviance information criterion
Robustness
Stability
Warfarin